短期雾霾刺激对健康成年人鼻腔炎性反应状态的影响

发布时间：2018-05-09 13:49

  本文选题：雾霾 + 空气污染　； 参考：《首都医科大学学报》2017年05期

【摘要】：目的观察短期重度雾霾对健康成年受试者鼻部症状、功能和炎性反应状态的影响。方法 23例居住于北京市中心的健康成年志愿者参与本项研究。分别于一次持续5 d的雾霾前后记录受试者的鼻部不适症状、检查其鼻功能、口鼻呼出一氧化氮(nitric oxide,NO)浓度,并收集鼻分泌物用于细胞因子浓度测定。结果在雾霾发生后的第二次访视中,受试者反映有不同程度的鼻部不适感,包括鼻堵、鼻痒、鼻干和鼻后滴漏等。鼻功能检查示鼻阻力由雾霾前的(0.18±0.01)Pa/(cm3·s)升高至雾霾后的(0.24±0.02)Pa/(cm3·s)(P=0.001);鼻腔容积由雾霾前的(15.06±052)cm3下降至雾霾后的(7.79±0.74)cm3(P=0.000);鼻腔最小截面积由雾霾前的(1.20±0.05)cm~2下降至雾霾后的(1.06±0.04)cm~2,差异有统计学意义(P=0.006)。与雾霾发生前相比较,经鼻或经口呼出NO浓度均在雾霾发生后明显升高。雾霾后,鼻分泌物中的Th2型细胞因子eotaxin和白细胞介素-5(interleukin-5,IL-5)、趋化因子C-C-基元配体7[chemokine(C-C motif)ligand 7,CCL7]、以及促炎性反应因子IL-8浓度显著升高,而Th1型细胞因子干扰素(interferon-γ,IFN-γ)以及免疫调节因子IL-10和转化生长因子-β(transforming growth factor-β,TGF-β)浓度显著下降。结论短期雾霾刺激可使健康成年人的鼻腔分泌物炎性反应介质倾向于Th2型分化,而参与免疫调节、抑制细胞增生、促进细胞外基质形成和损伤修复的细胞因子表达下降。鼻黏膜局部炎性反应状态的失衡一方面可直接使鼻腔有效通气面积减少,引发鼻部症状,另一方面可使个体易受过敏原、病原体或其他理化刺激的影响,这也是未来的研究方向。
[Abstract]:Objective to observe the effects of short term severe haze on nasal symptoms, function and inflammatory response in healthy adult subjects. Methods 23 healthy adult volunteers living in the center of Beijing participated in this study. The nasal symptoms of the subjects were recorded before and after a 5-day haze. The nasal function was examined. The nasal secretion was collected to determine the concentration of cytokines. Results during the second visit after haze, the subjects showed different degrees of nasal discomfort, including nasal obstruction, itching, dry nose and posterior nasal drip. Nasal function examination showed that nasal resistance increased from 0.18 卤0.01)Pa/(cm3 / s before haze to 0.24 卤0.02)Pa/(cm3 / haze, nasal cavity volume decreased from 15.06 卤052)cm3 before haze to 7.79 卤0.74 cm ~ (3) P ~ (-1) after haze, and the minimum cross-sectional area of nasal cavity decreased from 1.20 卤0.05)cm~2 before haze to 1.06 卤0.04 cm ~ (-2) after haze, the difference was statistically significant. Compared with those before haze, the concentration of no exhaled through nose or via mouth increased significantly after haze. After haze, the concentrations of Th2 type cytokines (eotaxin), interleukin-5 (IL-5), chemokine C-C- unit ligand 7 (chemokine(C-C motif)ligand 7- CCL7) and pro-inflammatory response factor (IL-8) in nasal secretion were significantly increased. But the concentrations of interferon- 纬 (IFN- 纬), IL-10 and transforming growth factor- 尾 (TGF- 尾) of Th1 type cytokine interferon- 纬 (IFN- 纬) and transforming growth factor- 尾 (TGF- 尾) decreased significantly. Conclusion Short-term haze stimulation can induce inflammatory response mediators in nasal secretion of healthy adults to differentiate into Th2 type, but participate in immune regulation, inhibit cell proliferation, promote the formation of extracellular matrix and decrease the expression of cytokines in injury repair. On the one hand, the imbalance of the local inflammatory reaction of nasal mucosa can directly reduce the effective ventilation area of nasal cavity, causing nasal symptoms, on the other hand, it can make individuals vulnerable to allergens, pathogens or other physical and chemical stimuli. This is also the future direction of research.
【作者单位】： 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科;北京市耳鼻咽喉科研究所北京市鼻病重点实验室教育部耳鼻咽喉头颈外科重点实验室;
【基金】：国家自然科学基金(81500771,81630023,81470678,81420108009) 北京市医院管理局人才培养“使命”计划(SML20150203) 首都临床特色应用研究(Z141107002514122) 首都卫生发展科研专项重点攻关项目(2016-1-2052) 北京市“百千万”人才项目(2016)~~
【分类号】：R765;X513
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本文编号：1866252