实验性自身免疫性葡萄膜炎模型中肝脏免疫系统紊乱的研究（英文）

发布时间：2018-05-12 16:52

本文选题：T细胞 + 葡萄膜炎　；参考：《生物化学与生物物理进展》2017年12期

【摘要】：葡萄膜炎是一种反复发作的炎症性疾病,可导致免疫系统功能障碍和多器官损伤.然而,葡萄膜炎是否导致肝功能损害尚不十分清楚.本文通过运用流式分析技术和激光共聚焦成像技术,研究了实验性自身免疫葡萄膜炎模型的肝脏病理和功能变化.结果显示肝损伤可出现在葡萄膜炎的炎症后期并与眼损伤程度相关.并且CD3~+CD4~+T细胞、CD3~-NK1.1~+DX5~-NK细胞、和CD11b~~+F4/80~-ly6c~+细胞在感染的眼睛和肝脏中增加.将CD3~+CD4~+T细胞回输给炎症的小鼠后,眼睛和肝脏的病理损伤加重.此外,在炎症的小鼠中可见血管扩张,大量淋巴细胞浸润到炎症的眼和肝脏的血管周围.总之,我们的研究结果提示,肝损伤可以发生在小鼠葡萄膜炎模型中,这种损伤可能与通过外周循环浸润到肝脏的CD3~+CD4~+T细胞有关.
[Abstract]:Uveitis is a recurrent inflammatory disease that can lead to dysfunction of the immune system and multiple organ damage. However, it is not clear whether uveitis leads to liver damage. The pathological and functional changes of liver in experimental autoimmune uveitis model were studied by flow analysis and confocal laser imaging. The results showed that liver injury could occur in the late stage of uveitis and correlated with the degree of ocular injury. And CD3 ~ CD4 ~ T cells, CD3 + -NK1.1 ~ DX5~-NK cells, and CD11bF4 / F4 / 80 ~ ly6c~ cells were increased in infected eyes and liver. The pathological damage of eyes and liver was aggravated after CD3 ~ CD4 ~ T cells were infused into inflammatory mice. In addition, vasodilation is seen in inflammatory mice, with large numbers of lymphocytes infiltrating the inflammatory eyes and around the blood vessels of the liver. In conclusion, our results suggest that liver injury may occur in mice with uveitis, which may be related to CD3 ~ CD4 ~ T cells infiltrating into the liver through peripheral circulation.
【作者单位】：山东中医药大学眼科所;山东省医科院基础医学研究所微生物室;
【基金】：supported by grants from The National Natural Science Foundation of China(81500710) Shandong Province Natural Science Foundation(ZR 2013HQ039) Projects of Medical and Health Technology Development Program in Shandong Province(2015WS0194) The Science and Technology Program from Shandong Academy of Medical Sciences(2015-25),Innovation Project of Shandong Academy of Medical Sciences~~
【分类号】：R773

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