LASEK与Epi-LASIK术后角膜中央知觉及泪膜稳定性的临床观察

发布时间：2018-05-13 14:46

本文选题：准分子激光上皮下角膜磨镶术 + 机械法准分子激光上皮瓣下角膜磨镶术　；参考：《新疆医科大学》2012年硕士论文

【摘要】：目的：探讨准分子激光上皮瓣下角膜磨镶术(LASEK)和机械法准分子激光上皮瓣下角膜磨镶术(Epi-LASIK)术后不同时间角膜中央知觉和泪膜稳定性的恢复情况。方法将60例(120眼)近视患者随机分为两组各30例(60只眼)，分别行LASEK和Epi-LASIK，在术后2w，4w,12w,24w对角膜中央知觉和泪膜稳定性的恢复情况进行随访，并行统计学分析。结果：LASEK组术后2周、4周测定的角膜中央知觉的值分别是44.85±5.78mm和49.85±5.01mm， Epi-LASIK组术后2周、4周时则为48.36±6.22mm和52.66士5.86mm，两组角膜中央知觉的结果对比，P㩳0.01，差异显著；术后12周LASEK和Epi-LASIK分别为55.55±4.02mm和56.31±4.60mm，两组结果对比P㩳0.05，差异有统计学意义；而术后24周两组分别为57.31±3.11mm和57.62±2.68mm，两组对比P㧐0.05,差异无统计学意义。泪膜稳定性表现为术后2周、4周时，非侵入性泪膜破裂时间在LASEK组分别为6.88±2.32s和9.06±3.15s，Epi-LASIK组为7.46±1.56s和9.62±1.29s，，两组对比P㩳0.05，差异有统计学意义；12周、24周LASEK组的值为11.21±5.13s和13.03±4.65s，Epi-LASIK组的值为12.06±0.98s和12.15±2.10s，两组对比P㧐0.05，差异无统计学意义。结论通过对术后早期泪膜稳定性、角膜中央知觉的恢复比较，Epi-LASIK术后相对较快的恢复及较少的术后并发症，表明Epi-LASIK优于LASEK。
[Abstract]:Objective : To investigate the restoration of corneal central perception and tear film stability at different time after LASIK ( LASEK and Epi - LASIK ) . The results showed that the values of central perception of cornea were 44.85 卤 5.78mm and 49.85 卤 5.01mm at 2w , 4w , 12w and 24w after operation . Results : The results showed that the central perception of cornea was 48.36 卤 6.22mm and 52.66 卤 5.86mm at 2w , 4w , 12w and 24w after operation .
LASEK and Epi - LASIK were 55 . 55 卤 4 . 02mm and 56.31 卤 4 . 60mm at 12 weeks after operation .
There was no statistically significant difference between the two groups ( 57.31 卤 3.11mm and 57.62 卤 2.68mm , P < 0.05 ) . The tear film stability was 6.88 卤 2.32s in LASEK group and 9.06 卤 3.15 s in LASEK group , and 7.46 卤 1.56s in Epi - LASIK group and 9.62 卤 1.29s in LASEK group .
In the 12 - week and 24 - week LASEK group , the values of the LASEK group were 11.21 卤 5.13s and 13.03 卤 4.65s , the values of Epi - LASIK group were 12.06 卤 0.98 s and 12.15 卤 2.10s , the difference was not statistically significant between the two groups .

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R779.63

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