男性OSAHS患者神经认知功能与睡眠结构的相关性

发布时间：2018-05-13 20:10

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 神经认知功能　；参考：《中国临床心理学杂志》2017年02期

【摘要】：目的:探讨男性OSAHS患者神经认知功能与睡眠结构的相关性。方法:采取病例对照研究,66名OSAHS患者和38名年龄、性别、文化程度相匹配的正常对照组分别完成蒙特利尔量表(MoCA)、韦氏成人记忆测验(WMS)、威斯康辛卡片分类测验(WCST)、Stroop色词测验(SCWT)及Epworth嗜睡量表(EES)的评估,并完成整夜多导睡眠描记检查(PSG)。结果:OSAHS组MoCA、WMS、WCST、SCWT各项分值与对照组的差异均具有显著性(Ps0.05或0.001)。OSAHS组EES分值高于对照组,睡眠效率、NREM 2期和REM期百分比明显低于对照组,进入REM睡眠时间也明显短于对照组(Ps0.05-0.01)。睡眠效率降低、觉醒次数增多、NREM4和REM期睡眠缩短,以及进入REM睡眠时间缩短均与OSAHS患者神经认知功能损害显著相关。结论:OSAHS患者的认知功能存在广泛损害,且与其睡眠结构异常密切相关。
[Abstract]:Objective: to investigate the correlation between neurocognitive function and sleep structure in male patients with OSAHS. Methods: a case-control study was conducted in 66 patients with OSAHS and 38 patients with age and sex. The normal control group with matched educational level completed the evaluation of Montreal scale, Wechsler adult memory test, Wisconsin card sorting test and Epworth sleepiness scale respectively, and completed the polysomnography all night. Results there were significant differences in the scores of EES between the two groups. The percentage of sleep efficiency and the percentage of NREM 2 and REM in the control group were significantly lower than those in the control group, and the time to enter REM sleep was significantly shorter than that in the control group (P < 0.05 or P < 0.01). The results showed that the EES score of the control group was significantly higher than that of the control group, and the percentage of sleep efficiency in the two groups was significantly lower than that in the control group (P < 0.05 or P < 0.05). The decrease of sleep efficiency, the increased number of awakenings and the shortening of sleep during NREM4 and REM, as well as the shortening of sleep time into REM, were significantly correlated with neurocognitive impairment in patients with OSAHS. Conclusion the cognitive function of patients with OSAHS has extensive impairment and is closely related to abnormal sleep structure.
【作者单位】：中南大学湘雅二医院精神卫生研究所;中南大学湘雅二医院呼吸内科;
【分类号】：R766

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