阻塞性睡眠呼吸暂停低通气综合征血栓前状态的影响因素分析

发布时间：2018-05-14 12:35

本文选题：血栓前状态 + 睡眠呼吸暂停低通气指数　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)血栓前状态的影响因素,为OSAHS患者静脉血栓栓塞症的预防提供依据和借鉴。方法:选取2013年6月至2016年7月在新疆医科大学附属第一医院经多导睡眠监测(PSG)明确诊断为OSAHS并进行了凝血、血栓与纤溶检测及炎症因子组合测定,同时排除存在其他可能影响凝血功能因素的患者共181名。其中符合血栓前状态参考标准的患者56名,为血栓前状态组,剩余125名患者凝血及血栓与纤溶检测不满足参考标准,即非血栓前状态组。分析、比较两组患者年龄、性别、民族、体重指数(BMI)、睡眠呼吸暂停低通气指数(AHI)、白介素-6(IL-6)、使用CPAP、合并慢性阻塞性肺疾病(COPD)和合并高血压的的情况。结果:非条件Logistic回归分析显示OSAHS血栓前状态的危险因素有年龄(OR=1.215,95%CI:1.104-1.337)、IL-6(OR=1.124,95%CI:1.015-1.244)、AHI(OR=1.207,95%CI:1.103-1.320)、合并COPD(OR=8.034,95%CI:1.819-35.488)。CPAP(OR=0.231,95%CI:0.059-0.901)是OSAHS患者血栓前状态的保护因素。结论:年龄、AHI、IL-6、合并COPD可能是OSAHS患者血栓前状态的危险因素,其中合并COPD可能是最重要的危险因素。CPAP是OSAHS患者血栓前状态的保护因素。
[Abstract]:Objective: to analyze the influencing factors of prethrombotic state of obstructive sleep apnea hypopnea syndrome (OSAHS) and to provide evidence and reference for the prevention of venous thromboembolism in patients with OSAHS. Methods: OSAHS was diagnosed by polysomnography in the first affiliated Hospital of Xinjiang Medical University from June 2013 to July 2016. Coagulation, thrombus and fibrinolysis were detected and inflammatory factors were determined. At the same time, 181 patients were excluded from other possible factors affecting coagulation function. Among them, 56 patients who met the reference standard of prethrombotic state were prethrombotic group, the remaining 125 patients did not meet the reference standard for coagulation, thrombus and fibrinolysis, that is, non-prethrombotic state group. Age, sex, nationality, body mass index (BMI), sleep apnea hypopnea index (AHI), interleukin-6 (IL-6), CPAP, chronic obstructive pulmonary disease (COPD) and hypertension were compared between the two groups. Results: Non-conditional Logistic regression analysis showed that the risk factors of prethrombotic state of OSAHS were as follows: CI1: 1.104-1.337T: CI1: 1.104-1.3371.12495: CI1: 1.015-1.244AHIOR1.207-95CIW 1.103-1.320, combined with COPDOR8.03495CIW 1.819-35.488. CPAPOR0.23195CICell 0.059-0.901 was the protective factor of prethrombotic state in OSAHS patients. Conclusion: COPD may be the risk factor of prethrombotic state in patients with OSAHS. COPD may be the most important risk factor. CPAP is the protective factor of prethrombotic state in OSAHS patients.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R766

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