OSAHS患者围手术期应用西吡氯铵含片的疗效研究

发布时间：2018-05-14 20:47

本文选题：睡眠呼吸暂停低通气综合症 + 阻塞性　；参考：《临床耳鼻咽喉头颈外科杂志》2017年14期

【摘要】：目的:探讨在OSAHS患者围手术期应用西吡氯铵含片对患者术后控制口咽局部炎症反应的作用。方法:选取确诊为OSAHS的患者60例,按照1:1的比例随机分为治疗组和对照组,采用随机单盲对照试验。治疗组给予西吡氯铵含片治疗,对照组不用,所有患者均行UPPP。比较两组患者术后1d、3d、5d口咽部疼痛情况、口咽部水肿情况、以及唾液中IL-1β、IL-8和TNF-α浓度。结果:试验组术后3d、5d的口咽部疼痛情况明显轻于对照组(P0.05);试验组术后3d、5d唾液中的IL-1β、IL-8和TNF-α明显低于对照组(P0.05)。结论:在UPPP术围手术期使用西吡氯铵含片能改善患者术后咽痛,改善口咽局部炎症反应,降低炎症因子的表达。
[Abstract]:Objective: to investigate the effect of cilpipramine buccal tablet on postoperative oropharyngeal inflammation in patients with OSAHS. Methods: sixty patients with OSAHS were randomly divided into treatment group and control group according to 1:1 ratio. The treatment group was treated with cepiramide buccal tablets, while the control group was not. All patients were treated with UPPP. The pain of oropharynx, edema of oropharynx and the concentration of IL-1 尾 -IL-8 and TNF- 伪 in saliva were compared between the two groups on the 1st and 3rd day after operation. Results: the oral and pharyngeal pain in the trial group was significantly lower than that in the control group on the 3rd and 5th day after operation, and the levels of IL-1 尾 IL-8 and TNF- 伪 in saliva of the trial group were significantly lower than that of the control group on the 3rd day after operation. Conclusion: the perioperative application of cepiramide buccal tablet in UPPP can improve the postoperative pharynx pain, improve the local inflammation of oropharynx, and decrease the expression of inflammatory factors.
【作者单位】：温州医科大学附属第一医院耳鼻咽喉科;玉环县人民医院耳鼻咽喉科;
【基金】：浙江省自然科学基金一般项目(No:LY14H130003) 浙江省医药卫生科技计划项目(No:2013KYB171)
【分类号】：R766.9

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