血管内皮功能与交感神经活性在OSAHS并发高血压发病机制中的价值

发布时间：2018-05-17 00:45

本文选题：OASHS + 高血压　；参考：《中国地方病防治杂志》2017年02期

【摘要】：目的分析OSAHS合并高血压血管内皮功能与交感神经活性的作用。方法打鼾患者115例依照血压测定、多导睡眠检测情况分为单纯OSAHS组(O组,39例),单纯高血压组(H组,35例),OSAHA合并高高血压组(OH组,41例),另外选本院同期健康体检人员无打鼾者50例作为对照组,测定睡眠前后患者血压、交感神经活性及血管内皮因子。结果O、OH组minSaO_2均显著低于对照组(P0.05),AHI显著高于H组和对照组(P0.05)。H、OH组睡前血压均显著高于对照组和O组(P0.05)。O、OH组睡眠NE水平显著高于睡眠前(P0.05)。醒后O、OH组内皮素均升高,NO下降,对照组和H组醒后内皮素下降,NO升高。O组NE与MDA正相关,醒后MAP与AHI、氧减指数、T90正相关,与minSaO_2负相关。NE与睡眠呼吸紊乱负相关,OH组内皮素与NP负相关。结论 OSAHS病情与交感神经活性增强有关。
[Abstract]:Objective to analyze the role of vascular endothelial function and sympathetic nerve activity in patients with OSAHS complicated with hypertension. Methods 115 patients with snoring were measured according to blood pressure. The polysomnography was divided into OSAHS group (n = 39), hypertension group (n = 35) and high hypertension group (n = 41). In addition, 50 healthy persons without snoring were selected as control group. Blood pressure, sympathetic nerve activity and vascular endothelial factor were measured before and after sleep. Results the minSaO_2 of the OOOOH group was significantly lower than that of the control group (P0.05AHI), which was significantly higher than that of the control group and the control group (P0.05AHI). The blood pressure before bedtime in the OOOH group was significantly higher than that in the control group and O group (P 0.05). The sleep NE level in the OOOH group was significantly higher than that in the control group (P 0.05). The levels of endothelin increased and no decreased in OFOH group after waking, while the level of endothelin in control group and H group increased after waking. NE and MDA were positively correlated in group O. MAP was positively correlated with AHI and oxygen reduction index (T90) after waking. There was a negative correlation between endothelin and NP in OH group. Conclusion the condition of OSAHS is related to the enhancement of sympathetic nerve activity.
【作者单位】：衡水市哈励逊国际和平医院职业健康查体科;
【基金】：衡水市科技局科研基金立项项目(编号:14004A)
【分类号】：R544.1;R766

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