胎盘生长因子在新生血管性眼病中的研究进展

发布时间：2018-05-18 21:55

  本文选题：胎盘生长因子 + 血管内皮生长因子受体　； 参考：《国际眼科杂志》2016年11期

【摘要】：新生血管是许多致盲性眼病的主要原因,例如糖尿病视网膜病变、早产儿视网膜病变、年龄相关性黄斑变性等。血管内皮生长因子(vascular endothelial growth factor,VEGF)在新生血管的形成中起着重要的作用,被认为是作用最强的血管生长因子。胎盘生长因子(placental growth factor,Pl GF)是VEGF家族中的一员,可促进新生血管生成,刺激内皮细胞迁移增殖,介导免疫炎症反应,且特异性表达于病理性新生血管,但在正常血管中不表达。因此近年来Pl GF逐渐受到人们关注。本文对Pl GF在新生血管性眼病中的作用机制进行探讨。
[Abstract]:Neovascularization is the main cause of blindness, such as diabetic retinopathy, retinopathy of premature infants, age-related macular degeneration and so on. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis and is considered to be the most effective vascular growth factor. Placental growth factor-PF is a member of VEGF family, which can promote angiogenesis, stimulate endothelial cell migration and proliferation, mediate immune inflammation, and express specifically in pathological neovascularization, but not in normal vessels. Therefore, in recent years, people pay more and more attention to Pl GF. In this paper, the mechanism of Pl GF in neovascular ophthalmopathy was discussed.
【作者单位】： 西安医学院;三二0一医院眼科;
【分类号】：R77
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本文编号：1907344