局部晚期鼻咽癌患者诱导化疗后行前程适形联合后程调强适形放疗效果观察

发布时间：2018-05-19 07:20

本文选题：局部晚期鼻咽癌 + -氟尿嘧啶　；参考：《山东医药》2017年18期

【摘要】：目的观察局部晚期鼻咽癌患者诱导化疗后行前程适形联合后程调强适形放疗的疗效。方法将56例局部晚期鼻咽癌患者随机分为观察组和对照组各28例,两组放疗前均采用顺铂联合5-氟尿嘧啶诱导化疗1~2个周期,观察组再行前程适形联合后程调强适形放疗,对照组行前程普通放疗联合后程适形调强放疗。放疗17次后,评价两组临床疗效,测量治疗前后肿瘤靶体积(CTV),统计危及器官(小脑、脑干和脊髓C_(1~4)、C_(5~7))物理计划剂量,记录前10次放疗的CTV适形度指数,观察放疗不良反应。结果观察组临床肿瘤控制率(53.57%)高于对照组(46.43%),但差异无统计学意义。两组治疗后CTV均小于治疗前(P均0.05),且观察组小于对照组(P0.05)。观察组小脑物理计划剂量低于对照组(P0.05),脑干和脊髓C_(1~4)、C_(5~7)物理计划剂量比较差异无统计学意义(P均0.05)。前10次放疗中,观察组CTV1、CTV2适形度指数达0.95~1.05者高于对照组(P均0.05)。观察组不良反应发生率35.71%,低于对照组的67.86%(P0.05)。结论局部晚期鼻咽癌患者诱导化疗后行前程适形联合后程调强适形放疗效果较好,且更安全。
[Abstract]:Objective To observe the curative effect of local advanced nasopharyngeal carcinoma (NPC) patients after inducible chemotherapy. Methods 56 patients with locally advanced nasopharyngeal carcinoma were randomly divided into the observation group and the control group (28 cases each). The two groups were treated with cisplatin combined with 5- fluorouracil for 1~2 cycles before radiotherapy. After 17 times radiotherapy, the two groups of tumor target volume (CTV) were measured, and the physical planned doses of endanger organs (cerebellum, brainstem and spinal C_ (1~4), C_ (5~7)) were measured, and the CTV conformability index of the first 10 radiotherapy was recorded, and the radiotherapy was observed. Results the control rate of the clinical tumor (53.57%) in the observation group was higher than that of the control group (46.43%), but the difference was not statistically significant. The CTV in the two groups was less than that before the treatment (P 0.05), and the observation group was less than the control group (P0.05). The physical plan dose of the cerebellar physical plan was lower than that of the control group (P0.05), the brain stem and spinal cord C_ (1~4), and the C_ (5~7) physical plan dose ratio. The difference was not statistically significant (P 0.05). In the first 10 radiotherapy, the CTV1, CTV2 conformability index of the observation group was higher than the control group (P 0.05). The incidence of adverse reactions in the observation group was 35.71%, lower than that of the control group (67.86% (P0.05)). Better, and safer.
【作者单位】：河南省人民医院;
【分类号】：R739.63

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