虾青素对凹透镜所致的豚鼠近视模型屈光状态及病理组织形态的影响

发布时间：2018-05-19 13:26

  本文选题：虾青素 + 近视　； 参考：《吉林大学学报(医学版)》2017年05期

【摘要】：目的:探讨虾青素对凹透镜所致的豚鼠近视模型屈光状态及病理组织形态的影响,阐明虾青素对近视屈光状态的改善作用。方法:48只健康豚鼠随机分为空白对照组(n=12)和模型组(n=36),模型组以远视性光学离焦法制备豚鼠右眼近视模型(左眼作为对照)后随机分为模型对照组、低(25ig·kg~(-1))和高剂量虾青素组(50ig·kg~(-1)),给药干预4周,于2和4周分别检测各组豚鼠双眼屈光度和眼轴长度,并于4周检测完成后,对右眼进行病理组织形态学检查。结果:模型组豚鼠在实验2周后实验眼球屈光度较作为对照的左眼低(P0.05),与空白对照组右眼比较也明显降低(P0.05),4周后更加明显(P0.01);模型组豚鼠在实验2周后实验眼球的眼轴长度较对照的左眼及空白对照组增加(P0.05),4周后增加更为明显(P0.01)。与模型组比较,虾青素组豚鼠眼屈光度及眼轴长度明显增加(P0.05),用药时间长且效果较好;其病理组织形态学上也呈现出明显的改善,胶原断裂现象明显减少且排列较整齐。结论:虾青素在改善近视眼屈光度及眼轴长度方面有良好的效果,还有助于恢复近视眼球巩膜的组织形态。
[Abstract]:Aim: to investigate the effect of astaxanthin on refractive state and histopathology of myopia induced by concave lens in guinea pigs, and to elucidate the effect of astaxanthin on myometropia. Methods Forty-eight healthy guinea pigs were randomly divided into two groups: control group (n = 12) and model group (n = 36). Low dose of astaxanthin (25 ig) and high dose of astaxanthin (50 ig) were given for 4 weeks. The diopter and the length of the eye axis were measured at 2 and 4 weeks, respectively. The histopathological examination of the right eye was performed after 4 weeks. Results: the diopter of the experimental eyeball in the model group was lower than that in the left eye of the control group 2 weeks after the experiment, and that in the model group was significantly lower than that in the right eye of the blank control group after 4 weeks, and that in the model group was significantly lower than that in the control group after 2 weeks. The axial length of the eyes increased more significantly than that of the left eye and the blank control group after 4 weeks, the increase of the axial length was more obvious than that of the control group and the blank control group. Compared with the model group, the diopter and the length of eye axis of astaxanthin group were significantly increased, the medication time was longer and the effect was better, the histopathology of astaxanthin group was also obviously improved, the phenomenon of collagen fracture was obviously reduced and arranged neatly. Conclusion: astaxanthin has a good effect in improving myopia diopter and axial length, and it is also helpful to restore myopia sclera histomorphology.
【作者单位】： 承德医学院附属医院眼科;
【基金】：河北省科技厅自然科学基金资助课题(H2015406054) 河北省承德市科技局自筹经费项目资助课题(201121058)
【分类号】：R778.11
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本文编号：1910275