新疆某三甲医院眼科雷珠单抗使用情况分析

发布时间：2018-05-20 04:12

本文选题：雷珠单抗 + 疾病构成　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:分析我院2013年至2015年雷珠单抗在不同疾病中的使用情况。方法:从本院医院管理信息系统(HIMS)中调取2013年1月1日至2015年12月31日应用雷珠单抗的全部病历数据,用Microsoft Excel软件对患者的性别、年龄、职业、区域、民族、疾病诊断、手术时间及手术名称等逐一进行数据整理及统计,部分数据用SPSS统计软件进行统计分析,了解不同疾病的性别、年龄、职业、区域、民族的构成情况,并对雷珠单抗的超说明书用药情况进行分析。结果:使用雷珠单抗的400例患者中,男女性别比为1.15:1,平均年龄为57.51±13.50岁,汉族:少数民族=1.31:1,职业以退(离)休人员为主,其次是职员及公务员,患者主要来源为天山北坡经济区。不同疾病中,以糖尿病视网膜病变患者居多,不同疾病的年龄的差异有统计学意义(X~2=112.186,P0.05),不同疾病的平均年龄差异有统计学意义(F=22.028,P0.05),不同疾病的职业构成差异有统计学意义(X~2=443.632,P0.05),不同疾病的性别构成差异无统计学意义(X~2=8.129,P0.05),不同疾病的民族构成差异无统计学意义(X~2=6.643,P0.05),不同疾病的患者区域差异无统计学意义(X~2=22.463,P0.05)。雷珠单抗使使用存在超说明书用药情况,主要体现在超适应症及波切术前用药时机上。在年龄相关性黄斑变性患者中规律用药组与不规律用药组两组患者年龄、性别、职业、区域来源构成差异无统计学意义。结论:使用雷珠单抗的患者中,不同疾病的年龄构成、平均年龄、职业差异存在统计学意义,而且我院雷珠单抗的使用存在超说明书用药情况,本次研究反应了我院雷珠单抗药物使用情况,为我院眼科专科建设及合理利用卫生资源提供依据,以提高用药的合理性和安全性,也为更进一步的研究调查提供依据。
[Abstract]:Objective: to analyze the use of Lei Zhu McAb in different diseases from 2013 to 2015. Methods: all the medical records from January 1, 2013 to December 31, 2015 were collected from the hospital management information system (HIMS), and the patients' sex, age, occupation, region, nationality and disease diagnosis were analyzed with Microsoft Excel software. The operation time and operation name were collected and counted one by one. Some of the data were analyzed by SPSS software to find out the constitution of sex, age, occupation, region and nationality of different diseases. The drug usage of the superspecification of Lei Zhu McAb was analyzed. Results: the sex ratio of male to female was 1.15: 1, the average age was 57.51 卤13.50 years old. The Han nationality: minority nationality was 1.31: 1. The occupation was mainly retired (retired), followed by staff and civil servant. The main source of the patients was the economic zone on the northern slope of Tianshan Mountain. Among the different diseases, diabetic retinopathy is the most common disease. The age difference of different diseases is statistically significant, the average age difference of different diseases is statistically significant, the difference of average age of different diseases is statistically significant, and the occupational composition of different diseases has statistical significance. There is no significant difference in the sex composition of different diseases. There was no significant difference in the national composition of different diseases. There was no significant difference in the regional differences between the patients with different diseases and the patients with different diseases. Threzhu McAb makes the use of superscript drugs mainly reflected in the superindications and the preoperation medication machine. There was no significant difference in age, sex, occupation and regional origin between regular and irregular drug groups in age-related macular degeneration patients. Conclusion: the age composition, average age and occupational difference of different diseases in patients with Leizhu McAb were statistically significant, and the usage of Lei Zhu McAb in our hospital was overstated. This study reflects the use of Leizhu McAb in our hospital and provides the basis for the construction of ophthalmological specialty and the rational use of health resources in our hospital in order to improve the rationality and safety of drug use and to provide the basis for further research and investigation.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R77

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