更昔洛韦对单纯疱疹病毒性角膜炎患者血清及泪液相关指标的影响

发布时间：2018-05-20 21:01

本文选题：更昔洛韦 + 单纯疱疹病毒性角膜炎　；参考：《海南医学院学报》2016年03期

【摘要】：目的:观察更昔洛韦对单纯疱疹病毒性角膜炎患者血清及泪液相关指标的影响。方法:选取本院收治的82例单纯疱疹病毒性角膜炎患者为研究对象,将82例患者随机分为对照组41例和观察组41例,对照组以阿昔洛韦进行治疗,观察组则以更昔洛韦进行治疗,然后将两组治疗前和治疗后3、7d及14d的血清及泪液氧化应激指标(NO、TAC、MDA及GSH-Px)及其他相关指标(β-MG、Zn、Cu、EGF)进行比较。结果:治疗前两组血清及泪液氧化应激指标及其他相关指标比较,差异均无统计学意义(P0.05);而治疗后3、7d及14d观察组的血清及泪液NO、MDA及β-MG、Cu、EGF水平均低于对照组,血清及泪液TAC、GSH-Px及Zn则高于对照组,且两组治疗后的检测水平均异于治疗前,差异均具有统计学意义(P0.05)。结论:更昔洛韦对善单纯疱疹病毒性角膜炎患者血清及泪液相关指标的改善更为明显,说明其对于疾病的治疗效果更好。
[Abstract]:Objective: to observe the effect of ganciclovir on serum and tear related indexes in patients with herpes simplex keratitis. Methods: 82 patients with herpes simplex keratitis were randomly divided into control group (n = 41) and observation group (n = 41). The control group was treated with acyclovir. The observation group was treated with ganciclovir, and then compared the serum and tear oxidative stress indexes (NOTACX, MDA, GSH-Px) and other related indexes (尾 -MGG ~ (2 +) ZnZN (Cu) EGF) before treatment and at 3 ~ 7 and 14 days after treatment. Results: there was no significant difference in serum and tear oxidative stress and other related indexes between the two groups before treatment, but the levels of serum and tear NOMDA and 尾 -MGCU EGF in the observation group were lower than those in the control group on the 7th and 14th day after treatment. The levels of GSH-Px and Zn in serum and tear were higher than those in the control group, and the levels of GSH-Px and Zn in the two groups after treatment were different from those before treatment, and the difference was statistically significant (P 0.05). Conclusion: ganciclovir is more effective in the treatment of herpes simplex keratitis than ganciclovir in patients with herpes simplex keratitis.
【作者单位】：沈阳市第四人民医院眼科;
【基金】：辽宁省科学技术计划项目(2011225014)~~
【分类号】：R772.21

【相似文献】