成年人阻塞性睡眠呼吸暂停低通气综合征患者血液凝血相关指标的临床研究

发布时间：2018-05-24 06:03

本文选题：成年人 + 阻塞性睡眠呼吸暂停低通气综合征　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:通过对与凝血功能相关血液指标的检测,探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者凝血功能的变化及其临床意义。方法:选择我院2014年1月~2016年7月期间55例OSAHS男性患者为研究组,分为轻中度阻塞组、重度阻塞组和轻中度低血氧组、重度低血氧组。以55例声带小结患者为对照组,检测研究组及对照组静脉血凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、血浆纤维蛋白原(FIB)、血小板数量(PLT)、血小板平均体积(MPV)的水平、血小板压积(PCT)、血小板分布宽度(PDW)。并在OSAHS组与对照组之间、不同阻塞程度和不同缺氧程度OSAHS患者之间进行比较,对结果进行分析,对相关问题进行讨论。结果:研究组与对照组相比,研究组PLT高于对照组,分别是244.71±52.29×10~9/L和215.27±50.67×10~9/L,差异有统计学意义(P=0.003)。PCT高于对照组,分别为0.203±0.037%和0.184±0.035%,差异有统计学意义(P=0.005)。余检测指标无明显差异(P0.05)。轻中度阻塞组与重度阻塞组相比,重度阻塞组RBC高于轻中度阻塞组,分别为5.31±0.69×1012/L和4.90±0.39×1012/L,差异有统计学意义(P=0.007).余各项指标对比无明显差异(P0.05)。轻中度底血氧组与重度底血氧组相比各项血生化指标对比无明显差异(P0.05)。结论:OSAHS患者存在血小板计数和血小板压积的影响,但总体凝血相关临床指标未见异常。
[Abstract]:Objective: to investigate the changes of coagulation function in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and its clinical significance. Methods: from January 2014 to July 2016, 55 male patients with OSAHS in our hospital were divided into three groups: mild to moderate obstructive group, severe obstructive group, mild to moderate hypoxic group and severe hypoxic group. The levels of prothrombin time (PTT), partial thromboplastin time (APTTT), thrombin time (TTT), plasma fibrinogen (FIBN), platelet count (PLT) and mean platelet volume (MPV) were measured in 55 patients with vocal nodules. Platelet pressure-accumulation (PCT) and platelet distribution width (PDW). The results were compared between OSAHS group and control group, OSAHS patients with different degrees of obstruction and hypoxia. The results were analyzed and the related problems were discussed. Results: compared with the control group, the PLT in the study group was higher than that in the control group (244.71 卤52.29 脳 10 ~ (9 / L) and 215.27 卤50.67 脳 10 ~ (9 / L) / L respectively), the difference was statistically significant (0.203 卤0.037% and 0.184 卤0.035%, respectively) compared with the control group. There was no significant difference in the remaining detection indexes (P0.05). The RBC of severe occlusion group was higher than that of mild to moderate occlusion group (5.31 卤0.69 脳 10 12 / L and 4.90 卤0.39 脳 10 12 / L respectively) compared with that of severe occlusion group (P 0.007). There was no significant difference in other indexes (P 0.05). There was no significant difference in blood biochemical indexes between mild and moderate basal blood oxygen group and severe basal blood oxygen group (P 0.05). Conclusion the effect of platelet count and platelet hematocrit was found in patients with OSAHS, but there was no abnormality in the clinical parameters related to total coagulation.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R766

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