阻塞性睡眠呼吸暂停低通气综合征患者血流变及血栓前标志物水平的研究

发布时间：2018-05-25 02:07

  本文选题：阻塞性睡眠呼吸暂停低通气 + 血流变　； 参考：《实用医学杂志》2016年16期

【摘要】：目的:检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血流变及血栓前标志物水平的变化,探讨OSAHS患者并发心脑血管血栓栓塞性疾病的可能机制。方法:选取经多导睡眠监测仪监测诊断的86例OSAHS患者,分为轻度组、中度组、重度组。选取20例健康者为正常对照组。检测各组间血流变指标及血栓前标志物水平并进行相关分析。结果:轻、中及重度OSAHS组患者全血粘度、红细胞聚集指数、红细胞电泳时间均高于正常对照组。不同程度OSAHS组患者血流变指标差异有统计学意义,且全血粘度、红细胞聚集指数、红细胞电泳时间随OSAHS程度加重而升高。OSAHS患者血浆粘度与正常对照组比较差异无统计学意义。OSAHS患者血浆中D-D、AT-Ⅲ、v WF的水平与正常对照组比较差异无统计学意义。结论:OSAHS患者存在血粘度、红细胞聚集升高、红细胞电泳时间延长等血流变异常改变,可能是OSAHS患者心脑血管血栓栓塞性疾病发生率增加的原因之一。
[Abstract]:Objective: to investigate the changes of hemorheology and prethrombotic markers in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and to explore the possible mechanism of cardiovascular and cerebrovascular thromboembolism in patients with OSAHS. Methods: 86 patients with OSAHS diagnosed by polysomnography were divided into mild group, moderate group and severe group. 20 healthy subjects were selected as normal control group. Blood rheological indexes and prethrombotic markers were measured and analyzed. Results: the whole blood viscosity, erythrocyte aggregation index and erythrocyte electrophoresis time of mild, moderate and severe OSAHS patients were higher than those of normal control group. There were significant differences in hemorheological indexes among patients with different degrees of OSAHS, and the whole blood viscosity, erythrocyte aggregation index, Erythrocyte electrophoresis time increased with the aggravation of OSAHS. There was no significant difference in plasma viscosity between patients with OSAHS and normal controls. There was no significant difference in plasma D-DX AT- 鈪，

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