隐性听力损失的发病机制及听力学表现

发布时间：2018-05-26 13:12

本文选题：隐性听力损失 + 谷氨酸-谷氨酰胺循环　；参考：《中华耳科学杂志》2017年02期

【摘要】：隐性听力损失是一种症状十分隐匿的阈上听觉感知功能缺陷,仅表现为噪声环境中言语识别率下降,临床上常规听力阈值检查无法发现,因此往往未引起重视。本文着重从耳蜗传入通路三个重要环节(包括内毛细胞、内毛细胞与螺旋神经节之间的突触和突触后传入通路)的障碍,耳蜗谷氨酸-谷氨酰胺循环障碍和耳蜗传出系统(包括外侧橄榄耳蜗束与耳蜗传入突触复合体形成的第三突触和内侧橄榄耳蜗束)的障碍来阐述隐性听力损失的发病机制和主客观听力学表现,从而为临床早期诊断隐性听力损失提供可靠的参考依据,并为隐性听力损失的早期干预提供理论和实验依据。
[Abstract]:Recessive hearing loss is a kind of subliminal auditory perception defect with very hidden symptoms. It only shows that the speech recognition rate in the noisy environment is decreased and the clinical hearing threshold can not be detected, so it is often ignored. This paper focuses on three important aspects of the afferent pathway of the cochlea, including the internal hair cells, the synapses and postsynaptic afferents between the inner hair cells and the spiral ganglia, and the postsynaptic afferent pathways. Impairment of the cochlear glutamate-glutamine circulation and the cochlear efferent system (including the third synapse and the medial olive cochlear bundle formed by the lateral olivary cochlear bundle and the cochlear afferent synaptic complex) to elucidate recessive hearing loss. Pathogenesis and subjective and objective audiological manifestations, It provides a reliable reference for early diagnosis of recessive hearing loss and provides theoretical and experimental basis for early intervention of recessive hearing loss.
【作者单位】：川北医学院附属医院耳鼻咽喉科;解放军总医院耳鼻咽喉头颈外科耳鼻咽喉研究所;
【基金】：国家重大科学研究计划项目(2014CB943001) 国家自然科学基金重点项目(81530032);国家自然科学基金(81470700H1304) 四川省教育厅课题(16ZB0231)~~
【分类号】：R764

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