阻塞性睡眠呼吸暂停低通气综合征患者血清解偶联蛋白-2水平的研究

发布时间：2018-05-30 10:06

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 解偶联蛋白-2　；参考：《山西医科大学》2012年硕士论文

【摘要】：目的：观察阻塞性睡眠呼吸暂停低通气综合征(OSAS)患者糖代谢异常情况及血清解偶联蛋白-2(UCP-2)的变化,探讨OSAS并发糖代谢异常的可能机制。方法：选取OSAS患者31例,分为轻中度组16人,重度组15人。选取OSAS合并2型糖尿病患者14人,单纯2型糖尿病患者14人及单纯肥胖者18例。各组间年龄、性别差异无显著性。入选者均测量身高、体重,算出体重指数(BMI)。所有入选者行整夜多导睡眠监测(PSG),分析得到睡眠呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(LSaO2)。监测次日晨7时抽取空腹静脉血10ml,分别测定糖化血红蛋白(HbA1c)、空腹血糖(FPG)及UCP-2水平,并比较各组间所有化验指标的差异,行相关性分析。结果：1.与肥胖对照组相比,其余各组FPG、HbA1C水平均明显升高,差异有统计学意义(p0.05)。重度OSAS组、合并组、糖尿病组与轻中度OSAS组相比,升高更明显,差异有统计学意义(P0.05)。合并组、糖尿病组与重度组相比,升高更明显(P0.05)。合并组与糖尿病组相比差异无统计学意义。 2.糖尿病组、重度OSAS组、合并组分别与对照组、轻中度组相比,UCP-2水平明显升高,差异有统计学意义(p0.05)。合并组与糖尿病组、重度组相比升高明显(p0.05)。轻中度组与对照组相比,差异无统计学意义。重度组与糖尿病组相比差异不明显。 3.相关分析显示UCP-2水平与AHI、HbA1c、FPG成正相关(r=0.795,0.513,0.268,p0.05),与LSO2呈负相关(r=-0.721,p0.05)。结论：1.OSAS患者存在糖代谢异常,并与OSAS严重程度有关； 2.OSAS可引起UCP-2的表达增加,其可能在OSAS所致糖代谢异常的发生、发展中起桥梁作用。
[Abstract]:Objective: to observe the abnormal glucose metabolism in patients with obstructive sleep apnea hypopnea syndrome (OSAS) and the changes of serum uncoupling protein-2 (UCP-2), and to explore the possible mechanism of abnormal glucose metabolism in patients with obstructive sleep apnea hypopnea syndrome (OSAS). Methods: 31 patients with OSAS were divided into mild and moderate group (16 cases) and severe group (15 cases). 14 patients with OSAS complicated with type 2 diabetes mellitus, 14 patients with type 2 diabetes mellitus and 18 patients with simple obesity were selected. There was no significant difference in age and sex among groups. Height and weight were measured and body mass index (BMI) was calculated. All the subjects were monitored with PSG through night polysomnography. The sleep apnea hypopnea index (AHI) and the lowest nocturnal oxygen saturation (LSAO _ 2) were obtained. The fasting venous blood samples were collected at 7: 00 the next morning to determine the levels of HbA1cG, FBG and UCP-2, and to compare the differences of all the test indexes among the groups, and to analyze the correlation between the two groups. The result is 1: 1. Compared with the obese control group, the levels of HbA1C in the other groups were significantly higher than those in the obese control group, and the difference was statistically significant (P 0.05). Severe OSAS group, combined group, diabetes group and mild to moderate OSAS group, the increase was more significant, the difference was statistically significant (P 0.05). In the combined group and the diabetes group, the increase was more obvious than that in the severe group (P 0.05). There was no significant difference between the combined group and the diabetic group. 2. The levels of UCP-2 in diabetic group, severe OSAS group and combined group were significantly higher than those in control group and mild to moderate group (P 0.05). Compared with diabetes mellitus group and severe group, the combined group was significantly higher than that of the severe group (P 0.05). There was no significant difference between mild and moderate group and control group. There was no significant difference between severe group and diabetes group. 3. Correlation analysis showed that there was a positive correlation between UCP-2 level and AHIHbA1cFPG, and a negative correlation between UCP-2 level and LSO2. Conclusion 1. There is abnormal glucose metabolism in patients with OSAS, and it is related to the severity of OSAS. 2.OSAS can increase the expression of UCP-2, which may play a bridge role in the pathogenesis and development of glucose metabolism abnormality induced by OSAS.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R766

【参考文献】