干眼患者症状与泪膜脂质层厚度的相关性

发布时间：2018-05-31 01:10

  本文选题：干眼 + 眼表疾病指数　； 参考：《眼科》2017年02期

【摘要】：目的研究干眼患者症状与泪膜脂质层厚度(LLT)的相关关系。设计回顾性病例系列。研究对象随机选取2015年7-10月就诊于北京同仁医院眼科门诊的干眼患者139例,其中男性58例,女性81例,年龄18~77岁,平均(37.75±12.86)岁。方法所有入组患者均进行眼表疾病指数(OSDI)问卷(共包括12项症状)调查以及用Lipi View~汶眼表面光干涉仪测量LLT。根据干眼症状(OSDI问卷评分)分为三组:轻度症状组35例(0~20分),中度症状组61例(21~45分),重度症状组43例(46~100分)。分析干眼症状与LLT的相关性以及不同程度干眼症状与LLT的关系。主要指标OSDI问卷评分、泪膜脂质层厚度。结果 139例干眼患者OSDI评分与LLT呈显著相关且为负相关(r=-0.256,P=0.002),随着OSDI得分增加(症状的加重)脂质层厚度变薄。OSDI问卷中异物感、眼酸痛、看电视、看电脑眼部不适与LLT有明显相关性(r=-0.206、-0.232、-0.190、-0.179,P均0.05),其他8项症状与LLT无相关性。严重程度不同的三个组别之间LLT存在差异,尤其是轻度症状组(64.89±16.40 nm)与重度症状组(54.65±14.48 nm)之间差异更明显(F=10.092,P=0.027);轻度症状组中LLT≤60 nm者14例(40%),而重度组中LLT≤60 nm者30例(70%)(χ~2=6.953,P=0.008)。结论干眼症状与泪膜脂质层厚度呈明显负相关。干眼症状中的异物感、眼酸痛、看电视或电脑眼部不适等症状与泪膜脂质层厚度相关性较显著。泪膜脂质层厚度低于60 nm者干眼症状严重。
[Abstract]:Objective to study the correlation between dry eye symptoms and tear film lipid layer thickness (LLTT). Design retrospective case series. Participants 139 dry eye patients (58 males and 81 females, 1877 years old with an average age of 37.75 卤12.86) were selected randomly from July to October 2015 in the ophthalmological outpatient department of Tongren Hospital in Beijing. Methods all the patients were investigated with OSD I questionnaire (including 12 symptoms) and measured by Lipi View- Munn Surface Light Interferometer. According to the score of OSDI of xerophthalmia, it was divided into three groups: mild symptom group (35 cases), moderate symptom group (61 cases) and severe symptom group (43 cases). To analyze the correlation between xerophthalmia and LLT and the relationship between xerophthalmia and LLT. Main outcome measures OSDI questionnaire score, tear film lipid layer thickness. Results there was a significant correlation between OSDI score and LLT in 139 patients with dry eye and a negative correlation was found. With the increase of OSDI score, the thickness of lipid layer became thinner. There was a significant correlation between computer ocular discomfort and LLT. There was no correlation between the other 8 symptoms and LLT. There were significant differences in LLT between the three groups with different severity, especially between the mild symptom group (64.89 卤16.40 nm) and the severe symptom group (54.65 卤14.48 nm), while in the mild symptom group, the LLT 鈮，

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