丙酸氟替卡松气雾剂对过敏性鼻炎患儿的临床研究

发布时间：2018-06-03 15:43

本文选题：丙酸氟替卡松气雾剂 + 过敏性鼻炎　；参考：《中国临床药理学杂志》2017年06期

【摘要】：目的观察丙酸氟替卡松气雾剂对过敏性鼻炎患儿的临床疗效及其对骨桥蛋白(OPN)、白细胞介素-4(IL-4)及白细胞介素-5(IL-5)表达的影响。方法将60例过敏性鼻炎患儿随机分为对照组和试验组,每组30例。对照组给予酮替芬1 mg,每天2次,口服;试验组给予丙酸氟替卡松气雾剂治疗,每次100μg,每天2次,2组均3个月为1个疗程,共治疗2个疗程。比较2组患儿的临床疗效,观察2组的白细胞介素(IL)-4、IL-5水平及OPN的免疫组化阳性染色的积分光密度值(IOD),并记录试验组治疗后的第1,3,6个月外周血中嗜酸性粒细胞,中性粒细胞,淋巴细胞计数。结果治疗后,试验组IL-4,IL-5,OPN水平分别为(66.31±18.00)ng·mL~(-1),(62.12±0.33)ng·mL~(-1),5589.71±267.00,对照组分别为(85.32±12.34)ng·mL~(-1),(30.24±0.30)ng·mL~(-1),(15.00±0.26)×10~3(P0.05)。试验组治疗后的第6个月外周血中嗜酸性粒细胞、中性粒细胞和淋巴细胞计数分别为(0.21±0.01)×10~9/L、(0.10±0.01)×10~9/L、(0.14±0.01)×10~9/L。对照组治疗后第6个月外周血中嗜酸性粒细胞、中性粒细胞和淋巴细胞计数分别为(0.21±0.02)×10~9/L、(0.10±0.01)×10~9/L、(0.14±0.01)×10~9/L。与治疗后1个月相比,差异均有统计学意义(P0.05),但2组差异无统计学意义(P0.05)。试验组总有效率为93.33%(28/30例),对照组为36.67%(11/30例),差异有统计学意义(P0.05)。试验组发生1例皮肤过敏,药物不良反应发生率为3.33%(1/30例);对照组发生皮肤过敏4例,鹅口疮3例,支气管痉挛伴哮喘3例,药物不良反应发生率为33.33%(10/30例,P0.05)。结论丙酸氟替卡松气雾剂治疗儿童过敏性鼻炎有较显著的临床疗效。
[Abstract]:Objective To observe the effect of Fluticasone Propionate Aerosol on the clinical efficacy of allergic rhinitis and the expression of osteopontin (OPN), interleukin -4 (IL-4) and interleukin -5 (IL-5) in children with allergic rhinitis. Methods 60 cases of allergic rhinitis were randomly divided into control group and experimental group, 30 cases in each group. The control group was given ketotifen 1 mg, 2 times a day, orally. The experimental group was treated with Fluticasone Propionate Aerosol, 100 mu g each time, 2 times a day and 1 courses for 3 months in 2 groups, and a total of 2 courses were treated. Compare the clinical curative effect of the 2 groups of children, observe the IL -4, IL-5 level and OPN immunomuction positive staining density value (IOD), and record the 1,3,6 of the test group after treatment. After treatment, the levels of IL-4, IL-5 and OPN were (66.31 + 18) ng. ML~ (-1), (62.12 + 0.33) ng. ML~ (-1), 5589.71 + 267 in the experimental group. The control group was (85.32 + 12.34) ng / mL~ (30.24 + 0.30) and (15 + 0.26). The number of eosinophils, neutrophils and lymphocyte counts in sixth months after treatment were (0.21 + 0.01) x 10~9/L, (0.10 + 0.01) x 10~9/L and (0.14 + 0.01) x 10~9/L. control group for sixth months of peripheral blood eosinophil, neutrophils and lymphocyte counts were (0.21 + 0.02) x 10~9/L and (0.10 + 0.01) * 10, respectively. ~9/L, (0.14 + 0.01) x 10~9/L. compared with 1 months after treatment, the difference was statistically significant (P0.05), but there was no statistically significant difference between the 2 groups (P0.05). The total effective rate of the experimental group was 93.33% (28/30 cases) and the control group was 36.67% (11/30), the difference was statistically significant (P0.05). The test group had 1 cases of skin allergy and the incidence of adverse drug reactions was 3.33% (1/3). 0 cases in the control group, 4 cases of skin allergy, 3 cases of goose aphtha, 3 cases of bronchial spasm accompanied by asthma, the incidence of adverse drug reaction was 33.33% (10/30, P0.05). Conclusion Fluticasone Propionate Aerosol has a significant clinical effect in the treatment of allergic rhinitis in children.
【作者单位】：湖北民族学院附属民大医院耳鼻咽喉头颈外科;湖北民族学院附属民大医院超声影像科;黄石市第一医院管理科;
【基金】：湖北省卫生厅科研一般基金资助项目(JX6B104)
【分类号】：R765.21

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