水合氯醛对豚鼠听性脑干反应的影响

发布时间：2018-06-08 21:46

  本文选题：麻醉药 + 水合氯醛　； 参考：《听力学及言语疾病杂志》2017年02期

【摘要】：目的探讨水合氯醛麻醉对成年豚鼠听性脑干反应检测的影响。方法分别在清醒状态(waking state,W)及水合氯醛(chloral hydrate,CH)麻醉状态下对20只健康成年雄性白色豚鼠进行短声(click)诱发的听性脑干反应(auditory brainstem response,ABR)检测,以引出率最高的波来判断反应阈值,比较两种状态下90dB peSPL刺激声强下ABR各波的潜伏期、波间期及不同强度下的Ⅱ、Ⅲ、Ⅳ波振幅及引出率。结果 20只豚鼠水合氯醛麻醉状态与清醒状态下ABR反应阈分别为25.50±2.76、28.5±3.66dB peSPL,差异无统计学意义(P0.05)。水合氯醛麻醉状态下ABR各波潜伏期较清醒状态均延长,Ⅲ、Ⅳ、Ⅴ波差异有统计学意义(P0.05),而Ⅰ、Ⅱ波差异无统计学意义(P0.05);水合氯醛麻醉状态下Ⅰ-Ⅴ、Ⅲ-Ⅳ、Ⅳ-Ⅴ波间期较清醒状态下延长(P0.05),而Ⅰ-Ⅱ、Ⅱ-Ⅲ波间期差异无统计学意义(P0.05);水合氯醛麻醉状态和清醒状态均显示波Ⅱ振幅及引出率最高;水合氯醛麻醉状态波Ⅱ、Ⅲ振幅在高强度刺激声时较清醒状态高,而波Ⅳ振幅较清醒状态低(P0.05)。结论水合氯醛麻醉及清醒状态下豚鼠ABR反应阈无明显差异,但水合氯醛麻醉会使豚鼠ABR的波Ⅲ、Ⅳ、Ⅴ潜伏期明显延长,并对振幅产生影响;豚鼠ABR波Ⅱ出现率最高,可以Ⅱ波判断反应阈。
[Abstract]:Objective to investigate the effect of chloral hydrate anesthesia on auditory brainstem response in adult guinea pigs. Methods A total of 20 healthy adult male white guinea pigs were subjected to auditory brainstem response (ABR) under anaesthesia of chloral anaesthesia and chloral anaesthesia. The auditory brainstem response (ABR) was measured by auditory brainstem response (ABR) in 20 healthy adult male guinea pigs. The highest response threshold was determined by the highest extraction rate. The latencies of ABR waves, the amplitudes of wave 鈪，

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