泪小点栓塞术对中度混合型干眼的疗效观察

发布时间：2018-06-10 18:36

本文选题：中度 + 混合型干眼　；参考：《中国现代医学杂志》2017年16期

【摘要】：目的观察泪小点栓塞术对中度混合型干眼患者眼部症状体征及炎症因子的影响,评价泪小点栓塞术对中度混合型干眼的疗效。方法对中度混合型干眼患者行泪小点栓塞术。对患者术前、术后30和60 d的OSDI评分、泪膜破裂时间(TBUT)、泪液分泌实验(未表面麻醉的Schirmer I)以及角膜荧光染色评分进行评估,并且测量泪液中炎症因子IL-1β、金属蛋白酶9(MMP-9)及TNF-α的表达,比较上述指标的变化。结果34例(68眼)中度混合型干眼患者术后与术前相比,干眼患者OSDI评分、角膜荧光染色评分下降,差异有统计学意义(P0.05);而泪液分泌实验、泪膜破裂时间差异无统计学意义(P0.05);泪液中炎症因子IL-1β,MMP-9及TNF-α的水平均出现了不同程度的降低,差异有统计学意义(P0.05)。结论泪小点栓塞术能改善中度混合型干眼患者的眼部症状体征,降低眼表炎症因子的水平。
[Abstract]:Objective to observe the effects of lacrimal dot embolization on ocular symptoms and inflammatory factors in patients with moderate mixed dry eye and to evaluate the effect of lacrimal dot embolization on moderate mixed dry eye. Methods lacrimal dot embolization was performed in patients with moderate mixed dry eye. OSDI scores, tear film rupture time (TBUTT), tear secretion test (unanesthetized Schirmer I) and corneal fluorescent staining were evaluated before and 30 and 60 days after operation. The expressions of IL-1 尾, MMP-9 and TNF- 伪 were measured and compared. Results the OSDI score and corneal fluorescent staining score of 34 patients with moderate mixed dry eye were significantly lower than those before operation (P 0.05). There was no significant difference in lacrimal film rupture time (P 0.05), but the levels of IL-1 尾, MMP-9 and TNF- 伪 in tear decreased to some extent, and the difference was statistically significant (P 0.05). Conclusion lacrimal dot embolization can improve the ocular symptoms and signs of moderate mixed dry eye patients and decrease the level of ocular surface inflammatory factors.
【作者单位】：南华大学第二附属医院眼科;衡阳师范学院;
【基金】：湖南省卫生计划生育委员会基金(No:B2015-57)
【分类号】：R779.6

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