PPI联合胃动力药与肉毒素注射治疗声带突肉芽肿疗效的比较研究

发布时间：2018-06-13 09:19

本文选题：声带突肉芽肿 + 咽喉反流　；参考：《临床耳鼻咽喉头颈外科杂志》2017年13期

【摘要】：目的:针对确诊的声带突肉芽肿,进行质子泵抑制剂(PPI)联合胃动力药物治疗与支撑喉镜下肉毒素注射治疗的对照研究,分析比较2种方法治疗声带突肉芽肿的有效性,以及对患者咽喉部症状和体征的缓解情况。方法:选取2014-12-2016-06期间就诊并符合纳入条件的38例声带突肉芽肿患者,根据患者的治疗意愿分为PPI联合胃动力药物组(28例,其中10例为肉毒素注射失败患者)及肉毒素注射治疗组(20例)。用症状指数量表及体征评分量评估患者治疗前后的症状及体征。结果:2组患者的年龄、性别、病程之间差异无统计学意义。PPI联合胃动力药物治疗的总有效率为96.43%;肉毒素注射组总有效率为45.00%。治疗前2组患者反流症状指数量表及咽喉反流体征量表评分差异无统计学意义;肉芽肿完全消失、复发时,2组患者反流症状指数量表及咽喉反流体征量表评分之间差异有统计学意义。结论:PPI联合胃动力药物治疗声带突肉芽肿的有效率及患者咽喉部症状和体征缓解率较肉毒素注射明显要高。
[Abstract]:Objective: to compare the efficacy of two methods in the treatment of vocal cord granuloma by proton pump inhibitor (PPI) combined with gastric motility drug therapy and botulinum toxin injection under supporting laryngoscope. And the relief of symptoms and signs of pharynx and larynx. Methods: a total of 38 patients with vocal cord granuloma were selected from 2014-12 to 2016-06 and were divided into two groups: PPI combined with gastric motility drugs group (n = 28). There were 10 cases of botulinum toxin injection failure and 20 cases of botulinum toxin injection group. The symptoms and signs of patients before and after treatment were evaluated with symptom index scale and sign score. Results there was no significant difference in age, sex and course of disease between the two groups. The total effective rate of PPI combined with gastric motility drugs was 96.43 and the total effective rate of botulinum toxin injection group was 45.00. There was no significant difference in the scores of reflux symptom index scale and throat reflux sign scale between the two groups before treatment, and the granuloma disappeared completely. The scores of reflux symptom index scale and throat reflux sign scale were significantly different between the two groups at the time of recurrence. Conclusion the effective rate of the treatment of vocal cord granulomatosis and the relief rate of symptoms and signs of pharynx and larynx of the patients treated with the combination of 10% PPI and gastric motility drugs were significantly higher than that of the injection of botulinum toxin.
【作者单位】：四川大学华西医院耳鼻咽喉头颈外科;
【基金】：国家自然科学基金(No:81170898,No:30801280) 四川省国际科技合作项目(No:2016HH0064) 卫生和计划生育委员会项目(No:150113)
【分类号】：R767.4

【相似文献】