老年阻塞性睡眠呼吸暂停低通气综合征患者髓过氧化物酶、细胞间黏附分子-1的表达

发布时间：2018-06-15 04:38

本文选题：髓过氧化物酶 + 细胞间黏附分子-　；参考：《中国老年学杂志》2017年20期

【摘要】：目的探讨老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清髓过氧化物酶(MPO)、细胞间黏附分子(ICAM)-1的表达及意义。方法通过多导睡眠监测仪(PSG)确诊的老年OSAHS患者93例为OSAHS组,根据睡眠呼吸暂停低通气指数(AHI)分为重、中、轻3组;选取31例健康老年体检者为对照组;酶联免疫吸附法(ELISA)测定入组者外周血ICAM-1、MPO浓度;重度OSAHS患者进行综合治疗3个月后复测ICAM-1、MPO,分析ICAM-1、MPO与PSG指标的相关性。结果老年OSAHS患者ICAM-1、MPO浓度随病情严重程度增加逐渐上升(F=29.937,18.946;P0.01);轻度组ICAM-1、MPO浓度与对照组无显著差异(P0.05);余各组相互比较均存在显著差异(P0.05)。OSAHS患者ICAM-1、MPO水平与体重指数(BMI)、年龄无明显关联(P0.05);OSAHS患者ICAM-1与MPO水平呈正相关,二者均和夜间最低血氧饱和度(Lsa O2)呈负相关,与AHI呈正相关(P0.01)。重度OSAHS患者经3个月综合治疗后外周血ICAM-1、MPO浓度及AHI显著降低,Lsa O2明显上升,和治疗前比较均有显著差异(P0.01)。结论老年OSAHS患者体内ICAM-1、MPO水平上升可能为其并发心血管损害的机制之一;外周血ICAM-1、MPO水平的测定对老年OSAHS病情判断、疗效评估及合并心血管病风险的预测有一定参考价值。
[Abstract]:Objective to investigate the expression and significance of serum myeloperoxidase (MPO) and intercellular adhesion molecule (ICAM-1) in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 93 elderly OSAHS patients diagnosed by PSG were divided into 3 groups according to sleep apnea hypopnea index (AHI), 31 healthy old people as control group. The concentration of ICAM-1 MPO in peripheral blood of patients with severe OSAHS was determined by Elisa, and the correlation between ICAM-1 MPO and PSG index was analyzed after 3 months of comprehensive treatment in patients with severe OSAHS. Results the concentration of ICAM-1 MPO in elderly patients with OSAHS increased gradually with the increase of severity of the disease. The concentration of ICAM-1 MPO in the mild group was not significantly different from that in the control group (P0.05), and there was significant difference between the other groups in the level of ICAM-1MPO and the body mass index (BMIA) in the patients with OSAHS. There was a positive correlation between ICAM-1 and MPO level in patients with OSAHS. Both of them were negatively correlated with the nocturnal minimum oxygen saturation (LSAO _ 2) and positively correlated with AHI (P 0.01). After 3 months of comprehensive treatment, the concentration of ICAM-1MPO and AHI in patients with severe OSAHS significantly decreased and LsaO2 increased significantly, and there was significant difference between them before treatment and before treatment (P 0.01). Conclusion the increase of ICAM-1 MPO level in elderly patients with OSAHS may be one of the mechanisms of cardiovascular damage, and the determination of ICAM-1 MPO level in peripheral blood may be of some reference value in judging the condition of OSAHS, evaluating the curative effect and predicting the risk of cardiovascular disease in the elderly patients with OSAHS.
【作者单位】：宝鸡市中心医院内科;
【分类号】：R766

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