鼻朗加糜蛋白酶治疗感染性鼻炎患儿的临床效果研究

发布时间：2018-06-15 20:37

本文选题：鼻郎 + 糜蛋白酶　；参考：《中华医院感染学杂志》2017年24期

【摘要】：目的探讨在儿童感染性鼻炎中运用生理性海水鼻腔喷雾器(鼻郎)加糜蛋白酶治疗的临床效果,旨在为今后临床治疗儿童感染性鼻炎提供参考与借鉴。方法前瞻性选取2013年1月-2017年1月医院儿科收治的98例患有感染性鼻炎儿童为研究对象,采用信封法分为试验组和对照组,每组各49例;对照组采用常规抗感染治疗,试验组在对照组的基础上,在生理性海水鼻腔喷雾器(鼻郎)中加入注射用糜蛋白酶4 000u配制成混合制剂进行喷鼻治疗;采用视觉模拟量表(Visual analogue scal,VAS)及Lund-kennedy评分评估感染性鼻炎患儿治疗前后的临床治疗效果;通过酶联免疫法监测两组治疗前后白细胞介素-17(IL-17)、IL-17受体(IL-17R)水平及免疫球蛋白IgE含量。结果试验组患儿总有效率95.92%,高于对照组81.63%(P0.05);治疗4周后,两组各项症状评分均有不同程度改善,且试验组改善程度优于对照组(P0.05);治疗2周后,两组血清中炎症介质IL-17、IL-17R水平及免疫球蛋白IgE含量均较治疗前有改善,且试验组改善程度优于对照组(P0.05)。结论将生理性海水鼻腔喷雾器(鼻郎)加糜蛋白酶运用于儿童感染性鼻炎治疗,能够迅速缓解患儿鼻部临床症状,具有高效、安全性能高、使用简便等优势。
[Abstract]:Objective to explore the clinical effect of physiologic seawater nasal spray plus chymotrypsin in the treatment of infective rhinitis in children in order to provide reference for clinical treatment of infective rhinitis in children. Methods 98 pediatric children with infectious rhinitis were prospectively selected from January 2013 to January 2017. They were divided into experimental group (n = 49) and control group (n = 49). On the basis of the control group, the experimental group added chymotrypsin 4000 u for injection into the physiologic sea water nasal spray (rhinorang) for nasal spray treatment. Visual analogue scalar vas and Lund-kennedy scores were used to evaluate the clinical therapeutic effect of children with infectious rhinitis before and after treatment, and the levels of IL-17 IL-17 receptor IL-17R and the content of immunoglobulin IgE were measured by enzyme-linked immunosorbent assay (Elisa). Results the total effective rate of the children in the test group was 95.92 and was higher than that in the control group (81.63 and P 0.05). After 4 weeks of treatment, the scores of symptoms in the two groups were improved to some extent, and the improvement degree of the test group was better than that of the control group (P 0.05), and after 2 weeks of treatment, the improvement was better than that of the control group. The levels of IL-17, IL-17R and immunoglobulin IgE in serum of the two groups were improved compared with those before treatment, and the improvement degree of the test group was better than that of the control group (P 0.05). Conclusion the application of physiologic sea water nasal sprayer plus chymotrypsin in the treatment of infective rhinitis in children can relieve the clinical symptoms of infective rhinitis of children quickly, and has the advantages of high efficiency, high safety performance and easy to use.
【作者单位】：青海红十字医院耳鼻喉科;
【基金】：国家自然科学基金资助项目(81102621)
【分类号】：R765.21

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