血清维生素D与2型糖尿病视网膜病变关系的研究

发布时间：2018-06-21 23:51

  本文选题：型糖尿病 + 糖尿病视网膜病变　； 参考：《复旦学报(医学版)》2017年05期

【摘要】：目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者视网膜病变(diabetic retinopathy,DR)与血清维生素D的关系。方法选取2012年2月至2014年12月期间同时被纳入上海市闵行区疾病预防控制中心生物样本库和糖尿病管理系统的2型糖尿病患者310例,根据眼底检查分为DR组(n=105例)和正常眼底(non diabetic retinopathy,NDR)组(n=205例),收集患者的基本信息、疾病史和检验信息,并检测各组血清中的25-羟基维生素D[25(OH)D]水平。结果单因素分析结果显示,与NDR组比较,DR组的25(OH)D水平降低(t=3.465,P0.001),25(OH)D缺乏率增高(χ~2=5.313,P=0.021),但是25(OH)D不足率差异无统计学意义(χ~2=0.990,P=0.320)。二元Logistic回归分析结果表明,在校正一系列变量(基本特征、疾病史、空腹血糖、餐后血糖、甘油三酯和尿酸)后,25(OH)D水平与T2DM患者并发DR呈负相关(OR=0.954,95%CI:0.926~0.983,P=0.002),25(OH)D缺乏的T2DM患者DR发病风险是25(OH)D不缺乏者的2.17倍(OR=2.171,95%CI:1.047~4.500,P=0.037)。结论血清25(OH)D水平与DR的发生呈负相关,25(OH)D缺乏可能与T2DM患者DR的发生有关。
[Abstract]:Objective to investigate the relationship between retinopathy Dr (Dr) and serum vitamin D in patients with type 2 diabetes mellitus (type 2 diabetes mellitusus T2DM). Methods from February 2012 to December 2014, 310 patients with type 2 diabetes were included in the Center for Disease Control and Prevention of Minhang District, Shanghai, and in the diabetic management system. According to fundus examination, Dr group (n = 105) and normal fundus (non diabetic retinopathy group (n = 205) were divided into two groups. Results the results of univariate analysis showed that the level of 25 (OH) D in Dr group was lower than that in NDR group (t = 3.465 / P 0.001) and the deficiency rate of 25 (OH) D was increased (蠂 ~ (2 / 2) ~ (5.313) P ~ (0.021), but there was no significant difference in 25 (OH) D deficiency rate (蠂 ~ (2 0.990) P ~ (0.320). The results of binary logistic regression analysis showed that in adjusting for a series of variables (basic characteristics, history of disease, fasting blood glucose, postprandial blood sugar), The level of 25 (OH) D in T2DM patients after triglyceride and uric acid was negatively correlated with Dr in T2DM patients (OR0.954 / 95CI: 0.926 / 0.983P0. 002). The risk of Dr in T2DM patients with 25 (OH) D deficiency was 2.17 times as high as that in patients with 25 (OH) D deficiency (OR2.171) 95CI1. Conclusion the level of 25 (OH) D in serum is negatively correlated with the incidence of Dr. It is possible that the deficiency of 25 (OH) D is related to the development of Dr in patients with T2DM.
【作者单位】： 上海市闵行区疾病预防控制中心;
【基金】：上海市闵行区自然科学研究课题(2015MHZ020) 上海市研究生教育创新计划 上海市公共卫生与预防医学Ⅰ类高峰学科建设计划~~
【分类号】：R587.2;R774.1
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本文编号：2050584