玻璃体腔注射lucentis治疗白内障术后顽固性黄斑水肿的疗效

发布时间：2018-06-24 13:24

本文选题：白内障术后 + 黄斑水肿　；参考：《第三军医大学学报》2016年20期

【摘要】：目的通过玻璃体腔单次注射抗血管内皮生长因子(vascular endothelial growth factor,VEGF)药物lucentis观察治疗顽固性黄斑水肿的临床疗效和安全性。方法收集2014年7月至2015年7月在我科白内障超声乳化联合人工晶体植入术后发生顽固性黄斑水肿患者9例(10眼),病史均大于3个月。荧光素眼底血管造影(fundus fluoresceinangiography,FFA)及光学相干断层扫描(optical coherence tomography,OCT)检查确诊并排除黄斑相关疾病引起的黄斑水肿。患眼玻璃体腔单次注射lucentis 0.5 mg(0.05 m L),治疗后随访12周,对比观察治疗前后患眼视力、眼压、OCT及FFA改变。结果 9例患者10只眼治疗后1周视力明显提高,4、12周后视力稳定;与治疗前比较,差异均具有统计学意义(P0.01)。OCT检查黄斑中心凹视网膜厚度(central foveal thickness,CFT),从治疗前(480±121)μm,下降至治疗后1周(293±58)μm,4、12周厚度分别保持在(231±23)、(235±35)μm,治疗前后比较,差异均具有统计学意义(P0.01),所有患者均未出现眼内或全身不良反应。结论玻璃体腔注射lucentis治疗白内障术后顽固性黄斑水肿能明显改善患者视功能,减轻黄斑水肿,无副作用。
[Abstract]:Objective to observe the clinical efficacy and safety of anti-vascular endothelial growth factor (vascular endothelial growth) -VEGF in the treatment of intractable macular edema by single injection of lucentis into vitreous cavity. Methods from July 2014 to July 2015, 9 patients (10 eyes) with macular edema developed after phacoemulsification and intraocular lens implantation in our department. Fundus fluorescein angiography (FFA) and optical coherence tomography (Oct) were used to diagnose and exclude macular edema caused by macular diseases. Lucentis 0.5 mg (0.05 mL) was injected into the vitreous cavity of the affected eyes. The visual acuity, intraocular pressure (Oct) and FFA were compared before and after 12 weeks follow-up. Results the visual acuity of 10 eyes of 9 cases was improved significantly after 1 week treatment and the visual acuity was stable after 12 weeks, which was compared with that before treatment. The difference was statistically significant (P0.01). Oct showed that the thickness of macular fovea retina (central foveal thicknessen decreased from (480 卤121) 渭 m before treatment to (293 卤58) 渭 m at (293 卤58) 渭 m at 12 weeks after treatment, and remained at (231 卤23), (235 卤35) 渭 m before and after treatment. The difference was statistically significant (P 0.01). No intraocular or systemic adverse reactions were found in all patients. Conclusion intractable macular edema after cataract surgery by intravitreal injection of lucentis can significantly improve visual function and alleviate macular edema without side effects.
【作者单位】：重庆医科大学附属第二医院眼科;
【分类号】：R779.6

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