Nd:YAG激光泪道成形术中应用妥布霉素地塞米松眼膏的疗效和安全性观察

发布时间：2018-06-25 17:32

本文选题：Nd + YAG激光泪道成形术　；参考：《中国药房》2017年35期

【摘要】：目的:观察钇铝石榴石激光泪道成形术(Nd:YAG激光泪道成形术)中应用妥布霉素地塞米松眼膏的临床疗效及安全性。方法:选取我院2013年1月-2017年1月在Nd:YAG激光泪道成形术中应用妥布霉素地塞米松眼膏治疗的阻塞性泪道疾病患者1 000例(1 250眼)的病历资料,按泪道阻塞的部位分为慢性泪囊炎组(380眼)、泪小(总)管阻塞组(360眼)、鼻泪管阻塞组(342眼)、泪小点阻塞组(86眼)及外伤性泪小管离断组(82眼)。5组患眼术中将稍加热后的妥布霉素地塞米松眼膏装入1 m L注射器内通过探针注入泪道内,边推注边退出探针。术后定期冲洗泪道,随访3个月。对各组疗效及安全性进行比较。结果:慢性泪囊炎组患眼术后治愈率为85.00%、有效率为87.63%,泪小(总)管阻塞组患眼术后治愈率为87.78%、有效率为94.45%,鼻泪管阻塞组患眼术后治愈率为89.18%、有效率为95.03%,泪小点阻塞组患眼术后治愈率为84.88%、有效率为94.18%,均显著高于外伤性泪小管离断组患眼的治愈率(42.68%)、有效率(64.63%),差异均有统计学意义(P0.05)。5组患眼不良反应发生率比较,差异均无统计学意义(P0.05)。结论:Nd:YAG激光泪道成形术在治疗慢性泪囊炎、泪小(总)管阻塞、鼻泪管阻塞、泪小点阻塞中应用妥布霉素地塞米松眼膏的疗效较好,且不良反应发生率较低。
[Abstract]:Objective: to observe the clinical efficacy and safety of tobramycin dexamethasone eye ointment in ND: YAG laser lacrimal duct angioplasty. Methods: the medical records of 1 000 patients (1 250 eyes) with obstructive lacrimal duct disease treated with tobramycin dexamethasone eye ointment in ND: YAG laser lacrimal duct angioplasty from January 2013 to January 2017 were selected. According to the location of lacrimal duct obstruction, the patients were divided into three groups: chronic dacryocystitis group (380 eyes), small lacrimal duct occlusion group (360 eyes), nasolacrimal duct obstruction group (342 eyes), lacrimal dot occlusion group (86 eyes) and traumatic lacrimal canaliculus disconnection group (82 eyes). Tobramycin dexamethasone eye ointment was injected into the lacrimal duct with a probe in a 1 mL syringe. Push and exit the probe. Lacrimal duct was flushed regularly after operation and followed up for 3 months. The efficacy and safety of each group were compared. Results: in the chronic dacryocystitis group, the postoperative cure rate was 85.00, the effective rate was 87.63, the postoperative cure rate was 87.78 and 94.455.The nasolacrimal duct obstruction group was 89.18, and the effective rate was 95.03. The cure rate was 84.88 and the effective rate was 94.18 in the plug group, which was significantly higher than that in the traumatic lacrimal canaliculus disconnection group (42.68%) and the effective rate (64.63%). The difference was statistically significant (P0.05). The difference was not statistically significant (P0.05). Conclusion the application of tobramycin dexamethasone ointment in the treatment of chronic dacryocystitis, obstruction of lacrimal (total) duct, obstruction of nasolacrimal duct and lacrimal dot is effective in the treatment of chronic dacryocystitis, and the incidence of adverse reactions is low.
【作者单位】：河北省眼科医院眼整形泪器科;
【分类号】：R779.6

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