SD-OCT后极部非对称性检查在青光眼早期诊断中的应用价值

发布时间：2018-06-26 04:16

本文选题：频域光学相干断层扫描 + 青光眼　；参考：《河北医科大学》2017年硕士论文

【摘要】：目的:探讨频域光学相干断层扫描技术(spectral-domain optical coherence tomography,SD-OCT)的后极部非对称性检查在青光眼早期诊断中的应用价值。方法:本研究选取2014年9月至2016年10月在我院眼病科就诊的早期青光眼患者23例(38眼)为青光眼组,另选取同期在我院健康体检的正常人20例(27眼)作为对照组。应用频域光学相干断层扫描技术对青光眼组和对照组受试者分别进行后极部非对称性检查,对比分析青光眼组和对照组后极部地形图的图像特征,以及后极部中央区、上方内环区、上方外环区、鼻侧内环区、鼻侧外环区、下方内环区、下方外环区、颞侧内环区和颞侧外环区视网膜厚度的变化。同时对两组受试者后极部分别进行单眼水平象限非对称性分析,并进行比较。结果:1本研究中对照组及青光眼组后极部均呈现中心凹视网膜最薄、内环较外环视网膜厚的形态特征;2青光眼组与对照组黄斑中心凹1 mm内视网膜厚度差异无统计学意义(P=0.308)。青光眼组内环、外环各象限视网膜厚度均比对照组变薄,且差异均有统计学意义(P0.05);3对照组后极部单眼水平象限非对称性分析结果为2.0(1.25 3.75),青光眼组后极部单眼水平象限非对称性分析结果为2.0(1.0,3.5),两组相比较,差异无统计学意义(P=0.35)。结论:1频域光学相干断层扫描仪的后极部非对称性检查能够快速、精确的测量后极部视网膜各参数,同时能对结构进行自动化分析;2其中监测后极部视网膜厚度可以作为青光眼早期诊断及病情追踪的重要手段;3不支持将后极部单眼水平象限非对称性分析作为青光眼早期诊断和评估病情的指标。
[Abstract]:Objective: to evaluate the application of spectral-domain optical coherence tomography-SD-Oct in the early diagnosis of glaucoma. Methods: from September 2014 to October 2016, 23 patients (38 eyes) with early glaucoma were selected as glaucoma group, and 20 healthy persons (27 eyes) were selected as control group. Frequency domain optical coherence tomography (OCTS) was used to examine the posterior pole asymmetry in glaucoma group and control group respectively. The image features of the posterior pole topographic map and the central region of the posterior pole were compared between the glaucoma group and the control group. The changes of retinal thickness in the upper inner ring, superior outer ring, nasal internal ring, nasal lateral outer ring, inferior internal ring, inferior outer ring, temporal internal ring and temporal outer ring. At the same time, the asymmetry of the posterior pole of the two groups was analyzed and compared. Results in this study, the posterior pole of the control group and the glaucoma group showed the thinnest fovea retina, and the retinal thickness of the inner ring was thicker than that of the outer ring. (2) there was no significant difference in retinal thickness within 1 mm fovea between the glaucoma group and the control group (P0. 308). The thickness of the inner ring and outer ring of each quadrant in the glaucoma group was thinner than that in the control group. The difference was statistically significant (P0.05). The results of asymmetric analysis of posterior polar horizontal quadrant were 2.0 (1.25 3.75) in the control group and 2.0 (1.0 卤3.5) in the glaucoma group. There was no significant difference between the two groups (P0. 35). Conclusion the asymmetry of the posterior pole can be measured quickly and accurately by using the 1 / 1 Frequency-Domain Optical coherence Tomography (OCT), and the parameters of the posterior pole retina can be measured accurately and quickly. It can be used to analyze the structure automatically. Monitoring the thickness of the posterior pole retina can be used as an important means for the early diagnosis of glaucoma and the tracking of the condition. 3. The asymmetric analysis of the horizontal quadrant in the posterior polar region is not supported Early diagnosis and evaluation of the disease by the light eye.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R775

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