鼻内光疗治疗成人变应性鼻炎的疗效及安全性的Meta分析

发布时间：2018-06-26 18:42

本文选题：鼻内光疗 + 鼻炎　；参考：《临床耳鼻咽喉头颈外科杂志》2017年24期

【摘要】：目的:系统评价鼻内光疗治疗成人AR的疗效及安全性,为临床应用提供循证医学证据。方法:搜索PubMed、Embase、Cochrane图书馆、中国学术期刊全文数据库(CNKI)、万方数据库,检索鼻内光疗治疗AR的随机对照试验(RCT)或临床研究文献,截止时间为2017年3月。依据文献纳入和排除标准进行文献筛选,采用Cochrane偏倚风险评估表对纳入文献进行质量评价。用Revman 5.3软件进行Meta分析,对计量资料计算加权均数差及其95%可信区间(CI),并绘制森林图及漏斗图,对计数资料计算比值比(OR)及其95%CI,并绘制森林图及漏斗图。采用鼻症状总评分(TNSS)、鼻结膜炎生活质量问卷(RQLQ)及上颚痒评分等指标评价鼻内光疗对成人AR的治疗效果,用鼻黏膜严重干燥及轻微干燥发生率评估安全性。结果:共纳入12篇文献,其中包括5篇RCT及7篇临床研究,包括615例成人AR患者。Meta分析显示:鼻内光疗患者治疗后较治疗前TNSS、RQLQ及上颚痒评分降低,鼻黏膜轻微干燥发生率较治疗前高,差异有统计学意义(P0.05),鼻黏膜严重干燥发生率高于治疗前,但差异无统计学意义(P0.05)。与安慰剂及抗组胺剂组比较,鼻内光疗组患者TNSS、RQLQ及上颚痒评分降低,鼻黏膜轻微干燥发生率较高,差异有统计学意义(P0.05),鼻黏膜严重干燥发生率较高,但差异无统计学意义(P0.05)。结论:鼻内光疗能改善患者的TNSS、RQLQ及上颚痒症状,安全性较好。对症状缓解不满意的患者可选择使用。
[Abstract]:Objective: to evaluate the efficacy and safety of intranasal phototherapy in the treatment of adult AR, and to provide evidence-based medical evidence for clinical application. Methods: we searched the PubMedus Embase Cochrane Library, CNKI, Wanfang database, and searched the randomized controlled trial (RCT) or clinical literature for AR treated by intranasal phototherapy. The deadline was March 2017. According to the criteria of literature inclusion and exclusion, the quality of included literature was evaluated by Cochrane bias risk assessment table. The weighted mean difference and its 95% confidence interval (CI) were calculated by using Revman 5.3 software. The forest map and funnel map were drawn, the OR and 95 CI were calculated for the counting data, and the forest map and funnel map were drawn. Total nasal symptom score (TNSS), rhinoconjunctivitis quality of life questionnaire (RQLQ) and maxillary itch score were used to evaluate the efficacy of intranasal phototherapy in the treatment of adult AR. Results: a total of 12 articles were included, including 5 RCT and 7 clinical studies, including 615 adult AR patients. Meta analysis showed that the TNSSN RQLQ and maxillary itch score were lower in patients with intranasal phototherapy than before treatment. The incidence of mild dry nasal mucosa was higher than that before treatment, the difference was statistically significant (P0.05), the incidence of severe dry nasal mucosa was higher than that before treatment, but the difference was not statistically significant (P0.05). Compared with placebo group and antihistamine group, TNSSN RQLQ and maxillary itch score were lower in intranasal phototherapy group, the incidence of mild dry nasal mucosa was higher (P0.05), the incidence of severe dry nasal mucosa was higher, but the difference was not statistically significant (P0.05). Conclusion: Intranasal phototherapy can improve TNSS RQLQ and maxillary itch symptoms. Patients who are not satisfied with symptom relief may choose to use it.
【作者单位】：西南医科大学附属医院耳鼻咽喉头颈外科;
【分类号】：R765.21

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