胎盘多肽注射液联合放化疗治疗中晚期鼻咽癌的疗效观察

发布时间：2018-06-29 06:44

本文选题：胎盘多肽注射液 + 鼻咽癌　；参考：《西部医学》2016年09期

【摘要】：目的观察胎盘多肽注射液联合放化疗治疗中晚期鼻咽癌的近期疗效和不良反应。方法将56例中晚期鼻咽癌患者随机分为治疗组28例和对照组28例,两组患者均接受调强适形放射治疗(intensity modulated radiation therapy,IMRT),同时予顺铂同步化疗,40mg/m2,每周1次,治疗组在此基础上加用胎盘多肽注射液辅助治疗。比较两组患者近期疗效和不良反应。结果两组患者均完成同步放化疗,两组总有效率无明显差异(P0.05);但治疗组患者体力状况评分较对照组明显改善,差异有统计学意义(醊2=5.203,P=0.023)。治疗组Ⅲ/Ⅳ度白细胞减少发生率明显低于对照组(P0.05);口腔黏膜炎及放射性皮肤反应发生率均明显低于对照组(P0.05)。结论胎盘多肽注射液联合同步放化疗治疗中晚期鼻咽癌有一定的辅助作用,能改善患者的体力状态,减轻或降低同步放化疗引起的毒副作用,无明显不良反应,值得临床进一步推广应用。
[Abstract]:Objective to observe the efficacy and side effects of placental polypeptide injection combined with radiotherapy and chemotherapy in the treatment of advanced nasopharyngeal carcinoma. Methods Fifty-six patients with advanced nasopharyngeal carcinoma were randomly divided into two groups: treatment group (n = 28) and control group (n = 28). All patients in both groups were treated with intensity modulated radiotherapy (IMRT) and 40 mg / m ~ (2) cisplatin chemotherapy, once a week. The treatment group was treated with placental polypeptide injection. The short-term curative effect and adverse reaction were compared between the two groups. Results there was no significant difference in the total effective rate between the two groups (P0.05), but the scores of physical condition of the patients in the treatment group were significantly improved compared with the control group, and the difference was statistically significant (P < 0.05). The incidence of leukopenia in the treatment group was significantly lower than that in the control group (P0.05), while the incidence of oral mucositis and radiation skin reaction was significantly lower in the treatment group than in the control group (P0.05). Conclusion placental polypeptide injection combined with concurrent radiotherapy and chemotherapy can improve the physical state of patients with advanced nasopharyngeal carcinoma, alleviate or reduce the side effects caused by concurrent radiotherapy and chemotherapy, and have no obvious adverse reactions. It is worthy of further clinical application.
【作者单位】：四川省医学科学院·四川省人民医院肿瘤科;
【基金】：四川省科技支撑计划项目(2015S2087)
【分类号】：R739.63

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