81例复发鼻咽癌的临床特征及预后因素分析

发布时间：2018-06-29 23:14

本文选题：鼻咽肿瘤 + 复发　；参考：《重庆医学》2016年24期

【摘要】：目的分析81例复发鼻咽癌患者的临床特征,探讨其预后因素。方法回顾分析2006年1月至2012年12月重庆市肿瘤医院放疗科治疗的复发鼻咽癌患者的临床材料,共81例,局部复发30例,区域复发2例,局部合并区域复发共49例。根据不同病情,对各个患者进行相应的综合治疗,分析影响治疗结果的各种可能因素。结果 46.8%复发发生在治疗后3年内,鼻咽腔及Ⅱ区分别是局部及区域复发率最高部位。再治疗后,1、2年的局部区域控制率分别为84.1%、76.1%,无疾病进展生存率分别为82.8%、75.1%,总生存率分别为65.7%、55.7%。多因素统计分析结果显示放疗分割模式、放射治疗技术、性别、鼻咽部的放疗剂量是影响其预后的主要因素。结论鼻咽癌初治失败可发生于不同部位,治疗失败后,经积极治疗,仍能使患者明显获益。
[Abstract]:Objective to analyze the clinical features of 81 patients with recurrent nasopharyngeal carcinoma and to explore the prognostic factors. Methods a retrospective analysis was made of the clinical materials of recurrent nasopharyngeal carcinoma patients in the Radiotherapy Department of Chongqing Cancer Hospital from January 2006 to December 2012. There were 81 cases of recurrent nasopharyngeal carcinoma, 30 local recurrence, 2 regional recurrence and 49 regional recurrence. The patient carried out a corresponding comprehensive treatment and analyzed the various possible factors affecting the outcome of the treatment. Results 46.8% recurrence occurred within 3 years after treatment. The nasopharyngeal cavity and the second region were the highest local and regional recurrence rates respectively. After retreatment, the local regional control rates of 1,2 years were 84.1%, 76.1%, and 82.8%, 75.1%, respectively, without disease progression, respectively. The total survival rate was 65.7% respectively. The results of 55.7%. multivariate statistical analysis showed that radiotherapy segmentation mode, radiotherapy technology, sex, and nasopharyngeal radiotherapy dose are the main factors affecting the prognosis. Conclusion the failure of nasopharyngeal carcinoma can occur at different sites. After the treatment failure, the patients can still benefit significantly after active treatment.
【作者单位】：重庆市南岸区人民医院公共卫生科;重庆市肿瘤医院放疗科;
【基金】：国家自然科学基金资助项目(11575038)
【分类号】：R739.63

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