视网膜静脉阻塞继发黄斑水肿抗VEGF治疗后黄斑区视网膜微结构变化

发布时间：2018-07-10 18:18

本文选题：视网膜静脉阻塞 + 黄斑水肿　；参考：《山东中医药大学》2017年硕士论文

【摘要】：目的:观察视网膜静脉阻塞继发黄斑水肿患者抗VEGF药物治疗1周前后视力、视网膜下积液、外界膜、椭圆体带以及脉络膜的变化,总结抗VEGF药物治疗的短期疗效。方法:选取56例RVO继发ME患者,玻璃体腔注射抗VEGF药物,通过OCT技术详细观察,并依据赋值表填写视网膜静脉阻塞患者抗VEGF治疗登记表。结果:临床观察统计,56例视网膜静脉阻塞继发黄斑水肿患者,抗VEGF药物治疗7天后,平均视力LogMAR由0.8855±0.52251提升为0.5648±0.45647(P=0.000);视网膜下积液患者比例治疗前后减少37%;外界膜和椭圆体带完整度分别由0.88±0.788和0.86±0.724减少为0.30±0.537和0.21±0.414(P值均为0.000);脉络膜厚度由治疗前318.18±47.423um变为320.54±45.551um(P=0.621)。结论:抗VEGF药物能够明显提高RVO继发ME患者视力,并促进视网膜下积液的吸收,改善外界膜和椭圆体带结构紊乱情况,但是对脉络膜厚度的变化无明显影响。
[Abstract]:Objective: to observe the changes of visual acuity, subretinal effusion, external membrane, ellipsoid zone and choroid in patients with macular edema secondary to retinal vein occlusion before and after one week of anti-VEGF treatment. Methods: 56 cases of secondary ME patients with RVO were treated with anti-VEGF by intravitreal injection. Results: 56 patients with macular edema secondary to retinal vein occlusion were treated with anti-VEGF drugs for 7 days. The mean visual acuity of LogMAR was increased from 0.8855 卤0.52251 to 0.5648 卤0.45647 (P = 0.000), the proportion of subretinal effusion patients decreased by 37 points before and after treatment, the integrity of external membrane and ellipsoid zone decreased from 0.88 卤0.788 and 0.86 卤0.724 to 0.30 卤0.537 and 0.21 卤0.414, respectively (P = 0.000), the thickness of choroid changed from 318.18 卤47.423um to 320.54 卤45.551um (P0.621). Conclusion: antiVEGF drugs can significantly improve the visual acuity of secondary ME patients with RVO, promote the absorption of subretinal effusion and improve the structural disorder of the outer membrane and ellipsoid zone, but have no significant effect on the change of choroidal thickness.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R774.1

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