银耳雾化液眼超声雾化治疗干眼症临床观察

发布时间：2018-07-14 07:53

【摘要】：目的:观察银耳雾化液眼部超声雾化治疗干眼症的临床疗效。方法:将干眼症患者55例(55眼,每例取1只眼)随机分为2组,中药组(A组)28例予银耳雾化液超声雾化,生理盐水组(B组)27例予生理盐水超声雾,对2组患者治疗前后临床症状、泪膜破裂时间(BUT)、基础泪液分泌试验(ST)、荧光素活体染色(FL)进行观察比较。另设门诊验光健康人群为健康对照组(C组)25例(25眼),作为检测干眼症泪液白细胞介素(IL)-1β的对照。结果:治疗后中药组干涩、异物感、分泌物增加症状改善率分别为65.38%、76.46%、75.00%,生理盐水组分别为30.77%、25.00%、10.00%,2组比较,差异均有统计学意义(P0.05,P0.01)。治疗后中药组FL积分下降、泪膜破裂时间(BUT)延长,与治疗前比较,差异有统计学意义(P0.01);且中药组FL、BUT指标改善较生理盐水组更显著(P0.05,P0.01)。治疗前中药组、生理盐水组泪液中IL-1β升高,与健康对照组比较,差异有统计学意义(P0.01);中药组、生理盐水组治疗前后IL-1β含量变化不大(P0.05)。治疗过程中所有患者均未发现相关不良反应。结论:银耳雾化液眼部超声雾化治疗干眼症安全有效;泪液中IL-1β可能参与干眼症的发生和发展,但本次治疗缓解干眼症状并非通过减少IL-1β机制起效。
[Abstract]:Objective: to observe the clinical effect of Tremella auricula nebulization liquid on dry eye. Methods: 55 cases (55 eyes) of dry eye were randomly divided into two groups: group A (28 cases) received ultrasonic atomization of Tremella auricula nebulization, and group B (27 cases) treated with normal saline ultrasonic fog. The clinical symptoms, tear film rupture time (but), basal tear secretion test (St) and fluorescein staining (FL) before and after treatment were observed and compared between the two groups. In addition, 25 cases (25 eyes) of healthy optometry in outpatient group were used as the control group for the detection of interleukin (IL)-1 尾 in tears of xerophthalmia. Results: after treatment, the improvement rates of dry, foreign body sensation and secretion increased symptoms were 65.38 and 76.46 / 75.00, respectively, and 30.7777 / 25.00 and 25.00 respectively in normal saline group. The difference was statistically significant (P0.05 / P0.01). After treatment, the FL score decreased and tear film rupture time (but) was prolonged in the Chinese medicine group (P0.01), and the improvement of FL-BUT index in the TCM group was more significant than that in the saline group (P0.05, P0.01). Before treatment, the levels of IL-1 尾 in the tears of the normal saline group were significantly higher than those of the healthy control group (P0.01); the content of IL-1 尾 in the Chinese medicine group and saline group had little change before and after treatment (P0.05). No adverse reactions were found in all patients. Conclusion: Tremella atomization fluid is safe and effective in the treatment of xerophthalmia, IL-1 尾 in tears may be involved in the occurrence and development of xerophthalmia, but this treatment does not reduce the mechanism of IL-1 尾.
【作者单位】：广州市天河区中医医院(天河区中心医院);
【基金】：广州市天河区科技计划项目(201209KW006)
【分类号】：R777.34

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