关于患者喉部增生肉芽组织摘除术的空气动力学分析

发布时间：2018-07-18 17:30

【摘要】：基于计算流体动力学(computational fluid dynamics,CFD)方法分析咽喉部阻塞患者手术摘除增生肉芽组织前后咽、喉及气道内相关空气动力学指标的变化及其对流场特征的影响,以期为术后临床效果的评估提供理论依据。首先通过患者手术前后的CT影像学数据,建立咽部、喉部及气道的三维有限元数值模型;然后采用计算流体动力学的方法,数值模拟并分析喉部肉芽组织摘除术前后咽、喉及气道内空气动力学特征的变化。结果显示:术后喉部异常结构形态改善显著,气道阻力下降明显,患者呼吸困难的症状在很大程度上得到了缓解。但由于术后患者喉部解剖结构的变化,使得患者吸气时出现气流扰动及局部负压的情况。这些结果表明通过对咽、喉及气道内空气动力学的分析研究,有助于找出造成空气动力学异常的关键解剖结构,咽喉及气道内流场的CFD数值模拟分析可以有效地评估喉部增生肉芽组织摘除术的临床效果。为开展个性化咽喉部阻塞治疗术提供更多的理论依据。
[Abstract]:Based on the computational fluid dynamics (computational fluid) method, the changes of relative aerodynamics in pharynx, larynx and airway before and after removal of hyperplastic granulation tissue in patients with pharynx and larynx obstruction were analyzed. In order to provide theoretical basis for the evaluation of postoperative clinical effect. The three-dimensional finite element numerical model of pharynx, larynx and airway was established by CT imaging data before and after operation, and then the pharynx was simulated and analyzed before and after laryngeal granulation tissue excision by computational fluid dynamics (CFD). Changes of aerodynamics in larynx and airway. The results showed that the abnormal structure of larynx was improved significantly, the airway resistance was decreased obviously, and the symptoms of dyspnea were alleviated to a great extent. But because of the change of anatomic structure of larynx after operation, airflow disturbance and local negative pressure occurred during inspiratory. These results suggest that the analysis of aerodynamics in pharynx, larynx and airways is helpful in identifying the key anatomical structures that cause aerodynamics abnormalities. CFD numerical simulation analysis of throat and airway flow field can effectively evaluate the clinical effect of laryngeal hyperplastic granulectomy. To provide more theoretical basis for individualized treatment of pharynx and larynx obstruction.
【作者单位】：常州大学生物医学工程与健康科学研究院常州市呼吸医学工程重点实验室;
【基金】：国家自然科学基金资助项目(11472062,11532003)
【分类号】：R767.91

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