盐酸氨溴索口服液治疗分泌性中耳炎的疗效观察

发布时间：2018-07-29 12:19

【摘要】：目的探讨盐酸氨溴口服液联合激素类喷鼻剂及抗生素治疗12岁及以上非阻塞性分泌性中耳炎的临床疗效,判断盐酸氨溴索口服液在治疗分泌性中耳炎中的作用,以期为分泌性中耳炎患者提供一种除标准桃金娘油肠溶胶囊外安全有效的治疗用药。方法将临床确诊、按时随访、遵从医嘱的2015年05月--2016年05月在我科门诊确诊的12岁及以上的非阻塞性分泌性中耳炎患者120例(135耳)作为研究对象,随机分为观察组和对照组,对照组予以口服标准桃金娘油肠溶胶囊、克拉霉素片及布地奈德鼻喷剂;观察组予以口服盐酸氨溴索口服液、克拉霉素片及布地奈德喷剂;正规治疗2周后,采用相关的临床标准对两组的治疗效果进行比较分析。结果临床确诊的患者在符合纳入标准后入组,分别对治疗前及治疗2周后的患者主诉、鼓膜象检查、声导抗及纯音听力测试结果进行比较。总体疗效评估采用χ2检验,对照组及观察组的临床有效率分别为75.0%、81.7%,声导抗对照组、观察组有效率分别为:75.0%、80.0%,两组比较差异无统计学意义(P0.05)。结论盐酸氨溴索口服液能够有效改善分泌性中耳炎的临床症状,提高患者的生活质量,具有和标准桃金娘油肠溶胶囊相同的临床价值,值得临床推广应用。
[Abstract]:Objective to investigate the clinical effect of ambroxol hydrochloride oral solution combined with hormone nasal spray and antibiotics in the treatment of non-obstructive secretory otitis media aged 12 years and above, and to evaluate the role of ambroxol hydrochloride oral solution in the treatment of secretory otitis media. In order to provide a safe and effective treatment for patients with secretory otitis media besides standard myrtle oil enteric capsule. Methods 120 patients (135 ears) with non-obstructive secretory otitis media diagnosed in our department from May 2015 to May 2016 were randomly divided into observation group and control group. The control group was treated with standard myrtle oil enteric capsule, clarithromycin tablet and budesonide nasal spray, while the observation group was given oral ambroxol hydrochloride, clarithromycin tablet and budesonide spray. After 2 weeks of regular treatment, the control group received oral ambroxol hydrochloride, clarithromycin tablet and budesonide spray. The therapeutic effects of the two groups were compared and analyzed by using the relevant clinical standards. Results the results of main complaint, tympanic film examination, acoustic conductance and pure tone hearing test were compared between the patients before treatment and 2 weeks after treatment. 蠂 2 test was used to evaluate the overall curative effect. The clinical effective rates of the control group and the observation group were 75.0% and 81.7, respectively, and the effective rates of the observation group were 75.0% and 80.0, respectively (P0.05). Conclusion ambroxol hydrochloride oral liquid can effectively improve the clinical symptoms of secretory otitis media and improve the quality of life of the patients. It has the same clinical value as the standard myrtle oil enteric-coated capsule and is worthy of clinical popularization and application.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R764.21

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