咖啡酸苯乙酯抑制鼻咽癌的作用机制研究
发布时间：2021-08-01 01:53
研究背景鼻咽癌（nasopharyngeal carcinoma,NPC）是一种特殊类型的头颈部恶性肿瘤,原发于解剖部位隐蔽的鼻咽部。NPC的发病有其独特的地理特点。NPC在东南亚,中国南方,尤其是广东、广西地区,年发病率约为30/10万,引发一系列严重的人群健康问题。而在美国或欧洲地区,其年发病率小于1/10万。NPC致癌过程是一个多步骤过程,目前发现NPC发病与EB病毒（Epstein-Barr virus,EBV）感染、遗传易感性、环境致癌因素密切相关。目前,NPC的治疗以放射治疗为主。随着调强放疗技术的发展,早期NPC患者通过放疗治疗5年生存率可以达到80%以上。然而,大部分NPC患者在初诊时已经处于中晚期,部分中晚期患者经过同步放化疗治疗后因肿瘤远处转移而治疗失败。因此,研发针对NPC的靶向药物,对放疗或化疗有增敏作用的药物,对提高中晚期NPC患者的疗效有积极意义。咖啡酸苯乙酯（caffeic acid phenethyl ester,CAPE）是一类多酚化合物。一些研究提示,CAPE具有抗癌,抗炎和免疫调节性质。其可以通过抑制肿瘤坏死因子（tumor necrosis fa...
【文章来源】：广西医科大学广西壮族自治区
【文章页数】：173 页
【学位级别】：博士
【部分图文】：
CAPE的化学结构
图 1-2：CAPE 单药对于 4 株 NPC 细胞系 CNE2、CNE2EBV、HK1 和 HK1EBV 的细胞活Figure 1-2: Effect of CAPE on viability of nasopharyngeal carcinoma (NPC) cell lines. CNE2, CHK1 and HK1-EBV cells were treated with 1–80 μM CAPE for 24, 48, and 72 h and cell vievaluated by CCK8 assay. Data are mean ±SD of three independent experiment
单药对于 4 株 NPC 细胞系 CNE2、CNE2EBV、HK1 和 HK1EBV 的ct of CAPE on viability of nasopharyngeal carcinoma (NPC) cell lines. CEBV cells were treated with 1–80 μM CAPE for 24, 48, and 72 h andK8 assay. Data are mean ±SD of three independent experiment
【参考文献】：
期刊论文
[1]Induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma[J]. Wen-Fei Li,Lei Chen,Ying Sun,Jun Ma. Chinese Journal of Cancer. 2016(11)
[2]Epstein-Barr virus and nasopharyngeal carcinoma[J]. Lawrence S.Young,Christopher W.Dawson. Chinese Journal of Cancer. 2014(12)
[3]A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China[J]. Ingemar Ernberg. 癌症. 2011(09)
[4]The prevalence and prevention of nasopharyngeal carcinoma in China[J]. Malcolm J. Simons. 癌症. 2011(02)
[5]Is nasopharyngeal cancer really a “Cantonese cancer”?[J]. Joseph Tien Seng Wee,Tam Cam Ha,Susan Li Er Loong. 癌症. 2010(05)
[6]Effect of caffeic acid phenethyl ester on proliferation and apoptosis of colorectal cancer cells in vitro[J]. Dong Wang, De-Bing Xiang, Zeng-Peng Li, Xiao-Hua Wu, Jiang-Hong Mou, Hua-Liang Xiao, Qing-Hong Zhang, Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China Yu-Jun He, Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China. World Journal of Gastroenterology. 2005(26)
本文编号：3314606
【文章来源】：广西医科大学广西壮族自治区
【文章页数】：173 页
【学位级别】：博士
【部分图文】：
CAPE的化学结构
图 1-2：CAPE 单药对于 4 株 NPC 细胞系 CNE2、CNE2EBV、HK1 和 HK1EBV 的细胞活Figure 1-2: Effect of CAPE on viability of nasopharyngeal carcinoma (NPC) cell lines. CNE2, CHK1 and HK1-EBV cells were treated with 1–80 μM CAPE for 24, 48, and 72 h and cell vievaluated by CCK8 assay. Data are mean ±SD of three independent experiment
单药对于 4 株 NPC 细胞系 CNE2、CNE2EBV、HK1 和 HK1EBV 的ct of CAPE on viability of nasopharyngeal carcinoma (NPC) cell lines. CEBV cells were treated with 1–80 μM CAPE for 24, 48, and 72 h andK8 assay. Data are mean ±SD of three independent experiment
【参考文献】：
期刊论文
[1]Induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma[J]. Wen-Fei Li,Lei Chen,Ying Sun,Jun Ma. Chinese Journal of Cancer. 2016(11)
[2]Epstein-Barr virus and nasopharyngeal carcinoma[J]. Lawrence S.Young,Christopher W.Dawson. Chinese Journal of Cancer. 2014(12)
[3]A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China[J]. Ingemar Ernberg. 癌症. 2011(09)
[4]The prevalence and prevention of nasopharyngeal carcinoma in China[J]. Malcolm J. Simons. 癌症. 2011(02)
[5]Is nasopharyngeal cancer really a “Cantonese cancer”?[J]. Joseph Tien Seng Wee,Tam Cam Ha,Susan Li Er Loong. 癌症. 2010(05)
[6]Effect of caffeic acid phenethyl ester on proliferation and apoptosis of colorectal cancer cells in vitro[J]. Dong Wang, De-Bing Xiang, Zeng-Peng Li, Xiao-Hua Wu, Jiang-Hong Mou, Hua-Liang Xiao, Qing-Hong Zhang, Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China Yu-Jun He, Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China. World Journal of Gastroenterology. 2005(26)
本文编号：3314606
本文链接：https://www.wllwen.com/yixuelunwen/wuguanyixuelunwen/3314606.html
最近更新
教材专著
