卡巴胆碱联合黄连素治疗创伤后肠功能障碍的临床疗效研究

发布时间：2017-12-28 04:34

本文关键词：卡巴胆碱联合黄连素治疗创伤后肠功能障碍的临床疗效研究　出处：《中国临床药理学杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的观察卡巴胆碱联合黄连素治疗创伤后肠功能障碍的临床疗效。方法 60例严重创伤患者随机分为试验组和对照组,各30例。对照组经胃管注入卡巴胆碱0.2 mg·kg~(-1),每天2次。试验组在对照组基础上加用生大黄粉20 g,温开水50 mL调匀后经胃管注入,每天2次。2组疗程均为7 d。观察2组患者的临床疗效、多器官功能障碍综合征(MODS)发生率、病死率。分别于治疗前、治疗后晨起对患者进行胃肠功能障碍评分、急性生理及慢性健康状况(APACHEⅡ)评分、MODS评分,测定二胺氧化酶、白细胞介素-6(IL-6)和胃动素水平。结果治疗后,试验组总有效率显著高于对照组(P0.05)。试验组MODS发生率、病死率均显著低于对照组(P0.05)。治疗后,试验组胃肠功能障碍评分、APACHEⅡ评分、MODS评分均较对照组显著降低(P0.05)。治疗后,试验组的二胺氧化酶、IL-6水平较对照组显著降低(P0.05);试验组的胃动素水平较对照组显著提高(P0.05)。结论卡巴胆碱联合大黄能明显改善肠功能障碍,特别是肠屏障功能障碍,能抑制炎症反应,取得良好的临床疗效,改善重症患者的预后。
[Abstract]:Objective To observe the clinical effect of Kaba choline combined with berberine in the treatment of intestinal dysfunction after trauma. Methods 60 patients with severe trauma were randomly divided into the experimental group and the control group, each with 30 cases. The control group was injected with Kaba choline 0.2 mg kg~ (-1) by gastric tube, 2 times a day. In the experimental group, the control group on the basis of rhubarbpowder 20 g, 50 mL after the temperature of boiling water and mix thoroughly into stomach 2 times a day. The 2 groups were 7 d. The clinical efficacy of the 2 groups, the incidence of multiple organ dysfunction syndrome (MODS) and the mortality rate were observed. Gastrointestinal dysfunction score, acute physiology and chronic health status (APACHE II) score and MODS score were measured before and after treatment respectively. The levels of two amine oxidase, interleukin -6 (IL-6) and motilin were measured. Results after treatment, the total effective rate of the test group was significantly higher than that of the control group (P0.05). The incidence and fatality rate of MODS in the test group were significantly lower than those in the control group (P0.05). After treatment, the score of gastrointestinal dysfunction, APACHE II score and MODS score in the experimental group were significantly lower than those in the control group (P0.05). After treatment, the level of two amine oxidase and IL-6 in the experimental group was significantly lower than that in the control group (P0.05), and the level of motilin in the experimental group was significantly higher than that in the control group (P0.05). Conclusion Kaba choline combined with rhubarb can obviously improve intestinal dysfunction, especially intestinal barrier dysfunction, inhibit inflammatory reaction, achieve good clinical effect and improve the prognosis of severe patients.
【作者单位】：杭州师范大学附属医院普外科;
【基金】：浙江省科技计划基金资助项目(2014C37031)
【分类号】：R641;R574
【正文快照】： (杭州师范大学附属医院普外科,杭州310015)XU Xin,MENG Ning,YU Yi-jun,HU Ming-rong(General Surgery,the Affiliated Hospitalof Hangzhou Normal University,Hangzhou 310015,China)严重创伤是导致青壮年死亡的常见因素,而创伤诱发的多器官功能障碍综合征(MODS)是主要死亡

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