Toll样受体10基因rs10004195位点多态性与Hp感染以及相关疾病的关系

发布时间：2018-01-01 11:21

本文关键词：Toll样受体10基因rs10004195位点多态性与Hp感染以及相关疾病的关系　出处：《安徽医科大学学报》2016年05期 　论文类型：期刊论文

【摘要】：目的探讨Toll样受体10(TLR10)基因rs10004.195位点多态性与幽门螺杆菌(Hp)感染以及相关疾病的关系。方法收集行胃镜活检的患者652例,同时采集患者外周血标本。采用免疫胶体金法检测患者外周血中Hp抗体,DNA直接测序方法检测TLR10基因rs10004195位点基因型。结果 TLR10基因rs10004195位点AA、TT和AT基因型分别为30.98%、20.71%、48.31%;Hp抗体阳性组TT基因型频率明显高于Hp抗体阴性组(P0.05)。Hp抗体阳性组中各疾病组与对照组基因型分布的比较,以及Hp抗体阴性组中各疾病组与对照组基因型分布的比较,差异均无统计学意义。结论 TLR10基因rs10004195位点多态性与Hp感染有易感相关性,而与Hp感染相关疾病无相关性。
[Abstract]:Objective to investigate the polymorphism of rs10004.195 locus in Toll like receptor 10TLR10 gene and Helicobacter pylori (HP). Methods 652 cases of gastroscopy biopsy were collected. At the same time, the peripheral blood samples of the patients were collected, and the HP antibody in the peripheral blood of the patients was detected by immunocolloidal gold method. The genotype of rs10004195 locus of TLR10 gene was detected by DNA direct sequencing. Results the TLR10 gene rs10004195 locus was AA. TT and AT genotypes were 30.98 and 20.71, respectively. The frequency of TT genotype in HP antibody positive group was significantly higher than that in HP antibody negative group. And the genotype distribution of each disease group and control group in HP antibody negative group were compared. Conclusion the polymorphism of rs10004195 locus of TLR10 gene is associated with HP infection, but not with HP infection.
【作者单位】：武汉大学人民医院检验科;
【基金】：国家临床重点专科建设项目(编号:财社[2010]305)
【分类号】：R573
【正文快照】： 幽门螺杆菌是人类最常见的慢性感染之一,不同的人群中,感染率有所不同,我国人群感染率为20%?80%11]。个体感染Hp后也并非全都发病,部分可能仅为Hp抗体阳性,而无任何病症,且Hp感染后所表现的疾病类型也不尽相同,Hp感染患者最终大约只有1%?2%会发展为胃癌[2],不同个体针对HP感染

【相似文献】