CRP、PCT、pANCA与炎症性肠病的相关性研究

发布时间：2018-01-06 15:15

本文关键词：CRP、PCT、pANCA与炎症性肠病的相关性研究　出处：《新疆医科大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:探讨C反应蛋白(CRP)、降钙素原(PCT)、核周型抗中性粒细胞胞浆抗体(pANCA)在炎症性肠病(IBD)中的临床价值。方法:本研究共纳入IBD患者67例,溃疡性结肠炎(UC)患者45例,克罗恩病(CD)患者22例,在健康人群中选取20名作为对照组。分别用免疫层析法检测CRP和PCT,酶联免疫吸附法(ELISA)检测pANCA,比较UC、CD和健康对照组血清CRP、PCT、pANCA水平的差异性。评估CRP、PCT、pANCA与UC、CD疾病活动性的关系,并通过联合检测了解三者对IBD的诊断意义。结果:血清CRP、PCT、pANCA水平在UC组、CD组及健康对照组中均存在显著差异,P均0.05。CD组血清CRP水平高于UC组,差异有统计学意义。CD组与UC组血清PCT水平不存在显著差异,P=0.4630.05。UC组pANCA阳性率(53.3%)高于CD组(18.2%),P=0.0130.0167,差异有统计学意义。CRP、PCT水平与IBD疾病活动度呈正相关,pANCA可以预测UC活动度,而对CD诊断意义不大。联合检测CRP、PCT和pANCA可以提高诊断的灵敏度。结论:血清CRP、PCT、pANCA水平在IBD和健康对照组中存在显著差异,对UC、CD有诊断和鉴别诊断意义,CRP、PCT与IBD活动度相关,pANCA可以预测UC活动度,左半结肠UC患者pANCA阳性率较高。
[Abstract]:Objective: to study the C-reactive protein (CRP) and procalcitonin (PCT). Clinical value of peripheral anti-neutrophil cytoplasmic antibody (pANCA) in inflammatory bowel disease (IBD). Methods: 67 patients with IBD were included in this study. 45 patients with ulcerative colitis and 22 patients with Crohn's disease were selected as control group. CRP and PCT were detected by immunochromatography. Elisa was used to detect pANCA, to compare the difference of serum levels of CRPT-pANCA between UCG-CD and healthy controls, and to evaluate the level of CRPc-PCT. The relationship between the activity of pANCA and the disease activity of UCG-CD and the diagnostic significance of the three methods to IBD by combined detection. Results: the level of serum CRPP-PCTpANCA was found in UC group. There were significant differences between CD group and healthy control group (P < 0.05). The serum CRP level in CD group was higher than that in UC group. There was no significant difference in serum PCT level between CD group and UC group. The positive rate of pANCA in the group of 0.4630.05.UC was higher than that in the group of CD (0.0130.0167), the difference was statistically significant. There was a positive correlation between PCT level and disease activity of IBD. PANCA could predict UC activity, but had little significance for CD diagnosis. PCT and pANCA can improve the sensitivity of diagnosis. Conclusion: there is a significant difference between IBD and healthy control group in the level of serum CRPP-PCT pANCA. CD has diagnostic and differential diagnostic significance. The correlation between CRPCT and IBD activity can predict UC activity, and the positive rate of pANCA in UC patients with left hemicolon is higher.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R574.62

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