乌司他丁静脉滴注联合生大黄煎液灌肠对重症胰腺炎患者的疗效及炎症因子水平的改善效果分析

发布时间：2018-01-11 08:09

本文关键词：乌司他丁静脉滴注联合生大黄煎液灌肠对重症胰腺炎患者的疗效及炎症因子水平的改善效果分析　出处：《中华中医药学刊》2016年07期 　论文类型：期刊论文

【摘要】：目的:探究乌司他丁静脉滴注联合生大黄煎液灌肠对重症胰腺炎患者的疗效及炎症因子水平的改善效果。方法:随机选取2009年6月—2013年6月医院收治的62例重症胰腺炎患者作为本次研究对象,根据入院时间先后将患者分成观察组和对照组各31例,对照组采用乌司他丁治疗,观察组采用乌司他丁联合大黄煎液灌肠治疗,观察并记录两组患者临床疗效,临床症状消退时间以及肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)等指标变化情况,分析比较。结果:治疗后,观察组共治愈15例,总有效率达93.55%,对照组总有效率只有74.19%,两组比较有统计学意义(P0.05)。两组患者治疗后TNF-α、IL-6和IL-8含量较治疗前均有显著下降,且观察组明显低于对照组患者,两组比较有统计学意义(P0.05)。经治疗后所有患者血清淀粉酶、谷丙转氨酶和白细胞计数较治疗前均有显著降低(P0.05),且观察组与对照组比较有明显差异(P0.05)。观察组患者腹痛、排气和排便等临床症状恢复时间均明显低于对照组患者,两组比较有统计学意义(P0.05)。结论:乌司他丁联合大黄煎液灌肠治疗重症胰腺炎患者临床疗效较好,各项临床症状在短时间内得到有效缓解,并且各项炎症因子水平明显降低,炎性反应减轻,有利于控制病情,促进恢复,提高患者生活质量。
[Abstract]:Objective: to investigate the effect of ulinastatin intravenous drip combined with rhubarb decoction enema on severe pancreatitis patients and improve the level of inflammatory factors. From June 2009 to June 2013, 62 patients with severe pancreatitis were randomly selected. According to the time of admission, the patients were divided into observation group (n = 31) and control group (n = 31). The control group was treated with ulinastatin and the observation group was treated with ulinastatin combined with rhubarb decoction enema. To observe and record the clinical curative effect, clinical symptom regression time and TNF- 伪 of tumor necrosis factor 伪 (TNF- 伪) in the two groups. The changes of interleukin-6 (IL-6) and interleukin-8 (IL-8) were analyzed and compared. Results: after treatment, 15 cases were cured in the observation group, the total effective rate was 93.55%. The total effective rate of the control group was only 74.19, there was significant difference between the two groups (P 0.05). After treatment, the contents of TNF- 伪 IL-6 and IL-8 in the two groups were significantly lower than those before treatment. And the observation group is significantly lower than the control group, the two groups have statistical significance (P 0.05). After treatment, all patients serum amylase. Glutamate-pyruvic transaminase and white blood cell count were significantly lower than before treatment, and there was a significant difference between the observation group and the control group (P 0.05). The abdominal pain in the observation group was significantly lower than that in the control group. The recovery time of clinical symptoms such as exhaust and defecation was significantly lower than that of the control group. Conclusion: ulinastatin combined with rhubarb decoction enema is effective in the treatment of severe pancreatitis patients, and all clinical symptoms are effectively alleviated in a short time. The level of inflammatory factors and inflammatory response were significantly decreased, which was beneficial to control the disease, promote recovery and improve the quality of life of patients.
【作者单位】：常山县人民医院;衢州市人民医院;
【分类号】：R576
【正文快照】： lower than the control group's.Two groups were statistically significant(P0.05).Conclusion:Ulinastatin combinedwith rhubarb decoction enema has better clinical efficacy in patients with severe pancreatitis.The clinical symptoms canbe effectively allevia

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