清热和胃理气降逆法联合PPI治疗胃食管反流病肝胃郁热证的临床疗效观察与机理探讨

发布时间：2018-01-13 17:02

本文关键词：清热和胃理气降逆法联合PPI治疗胃食管反流病肝胃郁热证的临床疗效观察与机理探讨　出处：《南京中医药大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：观察清热和胃理气降逆法联合PPI治疗胃食管反流病肝胃郁热证的临床疗效及对生活质量的影响,并根据现代药理研究探讨清热和胃理气降逆法的作用机理。方法：将符合纳入标准的60例患者,随机分为对照组和治疗组,每组30例,对照组给予雷贝拉唑钠肠溶片,治疗组予中药清热和胃理气降逆联合雷贝拉唑钠肠溶片,疗程8周,采用问卷调查方式,观察并记录治疗前后各组主要症状、次要症状及生活质量积分,进行疗效评定。全部数据以SPSS17.0统计软件进行统计学分析。结果：1.治疗后改善主要综合症状积分的总有效率治疗组和对照组分别为93.3%和70.0%,前者显著高于后者(P0.01)。2.两组均能降低主要单项症状积分(P0.01 或P0.05),治疗组缓解反流症状的疗效显著优于对照组(P0.01),而烧心、胸痛、反酸三症改善情况。两组无显著差异(P0.05)。3.治疗后改善次要症状积分的总有效率治疗组和对照组分别为96.7%和76.7%,前者显著高于后者(P0.01)。4.两组均能显著降低胃食管反流病患者的生活质量积分(P0.01),治疗组提高胃食管反流病患者生活质量的疗效明显优于对照组(P0.01)。结论：清热和胃理气降逆法联合PPI疗效显著,可显著改善肝胃郁热型胃食管反流病患者的临床症状,提高患者生活质量,安全性较高长期服用未见明显不良事件,值得进一步研究推广。
[Abstract]:Objective: To observe the clinical curative effect of clearing heat and regulating the stomach drop inverse method combined with PPI in the treatment of gastroesophageal reflux disease heat stagnation of liver and stomach and the influence on the quality of life, and according to modern pharmacological research to explore the mechanism of clearing heat and regulating the stomach drop inverse method. Methods: the 60 patients meeting the inclusion criteria were randomly divided into control group and treatment group, 30 cases in each group, the control group was given Rabeprazole Sodium Enteric-coated Tablets, treatment group was treated with traditional Chinese medicine and regulating the stomach drop inverse joint Rabeprazole Sodium Enteric-coated Tablets, after 8 weeks of treatment, by means of questionnaire survey, observe and record the main symptoms of each group before and after treatment, secondary symptoms and quality of life score, the efficacy was evaluated. All data were statistically analyzed by SPSS17.0 software. Results: the main symptoms improved 1. points after treatment the total effective rate of the treatment group and control group were 93.3% and 70%, the former was significantly higher than that of the latter (P0.01).2. The two groups can reduce the main individual symptom scores (P0.01 or P0.05), treatment group, remission of reflux symptoms was significantly better than the control group (P0.01), and heartburn, chest pain, acid regurgitation, three improvement. The two groups had no significant difference (P0.05) to improve the secondary symptom score after.3. treatment the total effective rate of the treatment group and the the control group were 96.7% and 76.7%, the former was significantly higher than that of the latter (P0.01.4.) of two groups were significantly reduced in patients with gastroesophageal reflux disease (P0.01) score of quality of life to improve the curative effect of gastroesophageal reflux, the life quality of patients was significantly better than the control group in the treatment group (P0.01). Conclusion: clearing heat and regulating the stomach significantly drop inverse method combined with PPI effect, can improve the clinical symptoms of liver and stomach swelter type gastroesophageal reflux disease patients, improve the quality of life of patients, higher safety of long-term use of no obvious adverse events, it is worthy of further study.

【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R571

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