某地既往有偿献血人员HCV感染情况及危险因素分析

发布时间：2018-01-31 13:10

本文关键词： 有偿献血丙型肝炎流行病学危险因素　出处：《南京医科大学学报(自然科学版)》2015年05期 　论文类型：期刊论文

【摘要】：目的 :了解江苏省某地区既往有偿献血人员丙型肝炎病毒(hepatits C virus,HCV)的感染情况并探讨其危险因素。方法:对该地区部分有既往有偿献血史的村民进行问卷调查和肝脏B超检查,并采集静脉血进行相关生化检测。应用Epi Data和SPSS软件对数据进行录入及统计学分析。结果:781名调查对象共检测出抗-HCV抗体阳性510例,感染率为65.3%,抗体阳性者中持续感染者占70.6%(360/510),自限清除者占29.4%(150/510)。HCV持续感染者以1b+3混合型(51.7%)和1b型(32.9%)为主。持续感染组丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、谷氨酰转移酶(GGT)的异常率高于未感染组和自限清除组。多因素Logistic回归分析显示性别、献全血史和单采血浆史是既往有偿献血人群感染HCV的危险因素,OR值分别为1.50、2.27和3.27;年龄是HCV感染慢性化的危险因素,OR值为1.62。结论 :既往有偿献血人群的HCV感染率处于较高水平,不洁采供血特别是单采血浆可能是导致HCV高感染率的主要原因。
[Abstract]:Objective: to investigate hepatitis C virus hepatitis C virus in paid blood donors in Jiangsu Province. Methods: questionnaire survey and liver ultrasound examination were carried out among some villagers who had paid blood donation history in this area. The venous blood was collected for biochemistry test. The data were recorded and analyzed by Epi Data and SPSS software. Results:. A total of 510 anti-HCV antibody positive cases were detected in 781 subjects. The infection rate was 65.3%, and 70.6% of the patients with positive antibody accounted for 30.6% of 510%. Those with self-limiting clearance accounted for 29.4m / 510n.HCV persistent infection were mainly 1b3 mixture (51.7) and 1b (32.9%). In the persistent infection group, alanine aminotransferase (alt). Alt. The abnormal rate of aspartate aminotransferase (AST) and glutamyltransferase (GGT) was higher than that of uninfected group and self-limited clearance group. Multivariate Logistic regression analysis showed sex. The OR values of whole blood donation history and plasma collection history were 1.500.27 and 3.27 respectively, which were the risk factors of HCV infection in paid blood donors. The OR value of age as the risk factor of chronic HCV infection was 1.62.Conclusion: the HCV infection rate in the former paid blood donors is at a high level. Unclean blood supply, especially plasma collection, may be the main cause of high infection rate of HCV.
【作者单位】：句容市人民医院感染科;南京医科大学公共卫生学院流行病与卫生统计学系;南京医科大学第一附属医院感染科;南京医科大学康达学院全科医学教研室;
【基金】：国家自然科学青年基金项目(81102164,81102165) 江苏省卫生厅医改科研项目(YG201413) 江苏高校优势学科建设工程资助(PAPD)
【分类号】：R512.63
【正文快照】： 丙型肝炎(简称丙肝)是由丙型肝炎病毒(hepatitis C virus,HCV)感染所引起的一种肝脏疾病,主要经过血液传播。HCV感染的特点是病毒血症水平低,发病隐匿,约80%的感染者会转为慢性感染,可导致肝脏慢性炎症和纤维化,部分患者可发展为肝硬化,甚至肝癌。HCV感染呈现全球流行趋势,据

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