溃疡性结肠炎肠黏膜组织中CPS1和S100P蛋白表达变化及意义

发布时间：2018-02-10 19:02

本文关键词： 溃疡性结肠炎上皮内瘤变氨甲酰磷酸合成酶 S钙结合蛋白P　出处：《山东医药》2017年10期 　论文类型：期刊论文

【摘要】：目的观察溃疡性结肠炎(UC)肠黏膜组织中结肠癌相关蛋白氨甲酰磷酸合成酶1(CPS1)和S100钙结合蛋白P(S100P)的表达变化,并探讨其临床意义。方法收集20例UC急性期及其对应缓解期、30例UC伴上皮内瘤变肠镜活检标本,采用免疫组化法检测各组织中CPS1和S100P蛋白,并分析其相关性。结果在UC缓解期与急性期肠黏膜组织中CPS1和S100P表达量比较无统计学差异(P均0.05),均低于UC伴上皮内瘤变肠黏膜组织中CPS1和S100P表达量(P均0.01)。在UC缓解期、急性期、伴上皮内瘤变肠黏膜组织中,CPS1和S100P表达均无相关性(r分别为0.197、0.146、0.042,P均0.05)。结论在UC伴上皮内瘤变肠黏膜组织中CPS1和S100P表达增加,二者可能独立参与UC肠黏膜上皮内瘤变过程,而在UC急性期病程发展中无明确作用。
[Abstract]:Objective to observe the expression of colon cancer associated protein carbamyl phosphate synthase 1 (CPS1) and S100 calcium binding protein (S100 S100P) in the intestinal mucosa of Ulcerative Colitis (UC). Methods 20 cases of UC in acute stage and 30 cases of UC with intraepithelial neoplasia were collected. Immunohistochemical method was used to detect CPS1 and S100P protein in the tissues. Results there was no significant difference in the expression of CPS1 and S100P between UC remission and acute intestinal mucosa tissues, which was lower than that in UC with intraepithelial neoplasia and intestinal mucosal tissue (P < 0.01), and in the remission stage and acute stage of UC, there was no significant difference in the expression of CPS1 and S100P, and there was no significant difference in the expression of S100P and S100P between the two groups. There was no correlation between the expression of CPS1 S1 and S100P in intestinal mucosa with intraepithelial neoplasia. The expression of CPS1 and S100P in intestinal mucosa of UC with intraepithelial neoplasia were all increased, and the expression of CPS1 and S100P might be independently involved in the process of UC intestinal epithelial neoplasia. However, there was no definite effect in the course of UC in acute stage.
【作者单位】：南京中医药大学附属医院;
【基金】：江苏省高校优势学科建设工程资助项目(012062003010) 江苏省中医院院级课题(Y14078)
【分类号】：R574.62

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