硫化氢在评价急性胰腺炎严重程度中的作用研究

发布时间：2018-02-11 17:45

本文关键词： 胰腺炎急性坏死性硫化氢诊断鉴别　出处：《重庆医学》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨硫化氢(H2S)在急性胰腺炎(AP)严重性程度评价中的价值。方法选取2013年2月至2015年12月期间在该院住院的51例AP患者,其中21例为重症AP(SAP)组,30例为轻性AP(MAP)组,同时抽取36例非胰腺炎腹痛患者(腹痛组),9例健康人作为对照组(NC组)。入院时抽取4组受试者外周静脉血,并进行Ranson评分。在12、24、48h后继续抽取AP患者外周静脉血,使用酶联免疫吸附法(ELISA)监测患者血清H2S水平。使用单因素方差分析和事后分析比较4组受试者入院时血清H2S水平,重复测量的方差分析比较AP患者入院时、12h、24h和48h时H2S水平,Spearman相关性分析AP患者血清H2S水平与Ranson评分的关系。结果入院时,SAP组的H2S水平显著高于MAP组、腹痛组、NC组(P=0.000),MAP组的H2S水平也显著高于腹痛组、NC组(P=0.000),而腹痛组和NC组差异无统计学意义(P=0.131);AP患者在入院时,12h,24h和48h时H2S水平差异均有统计学意义(P=0.000),呈逐渐下降的趋势;AP组入院时的H2S水平与Ranson评分呈显著正相关(r=0.578,P=0.000)。结论血清H2S对诊断患者是否存在AP发生的可能性上有明确意义,血清H2S水平越高,AP为SAP的风险越大。
[Abstract]:Objective to evaluate the value of H2S in evaluating the severity of acute pancreatitis (AP). Methods 51 patients with AP were selected from February 2013 to December 2015, including 21 patients with severe APSAP (n = 30) and 30 patients with mild APAP MAPP (n = 30), who were hospitalized in the hospital from February 2013 to December 2015. At the same time, 36 patients with non-pancreatitis abdominal pain (9 healthy persons in the abdominal pain group) were selected as control group. Peripheral venous blood was taken from 4 groups of subjects on admission, and the Ranson score was evaluated. The peripheral venous blood of AP patients continued to be drawn after 1224 hours. The serum H2S levels were monitored by Elisa. The serum H2S levels were compared between the four groups at admission using one-way ANOVA and hindsight analysis. The relationship between serum H2S level and Ranson score in AP patients at 12h and 48h after admission. Results the H2S level in SAP group was significantly higher than that in MAP group at admission. The level of H2S in map group was significantly higher than that in NC group in abdominal pain group, but there was no significant difference between abdominalgia group and NC group. There were significant differences in H2S level in patients with AP at 12 hours after admission and 48 hours after admission, showing a decreasing trend of AP. There was a significant positive correlation between H2S level and Ranson score at admission. Conclusion Serum H2S has a definite significance in diagnosing the possibility of AP in patients. The higher the serum H 2S level, the greater the risk of AP being SAP.
【作者单位】：重庆市第九人民医院消化内科;
【分类号】：R576

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