益生菌治疗重症急性胰腺炎的随机对照试验Meta分析

发布时间：2018-02-24 16:37

本文关键词： 益生菌重症急性胰腺炎 Meta分析　出处：《重庆医学》2017年19期 　论文类型：期刊论文

【摘要】：目的系统评价益生菌在重症急性胰腺炎(SAP)治疗中的安全性和有效性。方法检索PubMed、Embase、Cochrane Library、Medline、中国生物医学文献服务数据库(CBM)、中文科技期刊数据库(VIP)、相关期刊论文(CNKI)、万方学术期刊全文数据库,全面查找益生菌治疗SAP的临床随机对照试验(RCTs),采用Review Manager5.3软件进行统计分析。结果共纳入12篇RCT研究,共910例患者,Meta分析结果显示:益生菌组与对照组在病死率[RR=0.97,95%CI(0.63,1.49),P=0.88]、多器官功能障碍发生率[RR=0.72,95%CI(0.49,1.06),P=0.10]及胰腺相关感染率[RR=0.76,95%CI(0.54,1.07),P=0.12]等方面比较,差异均无统计学意义;但两组住院时间[MD=-3.74,95%CI(-6.37,-1.12),P=0.005]及肠缺血坏死发生率[RR=11.39,95%CI(1.5,86.4),P=0.02]比较,差异均有统计学意义。结论益生菌不能有效改善SAP患者的相关临床指标,同时会增加患者肠缺血坏死的发生风险,但可以缩短患者的住院时间。
[Abstract]:Objective to evaluate the safety and efficacy of probiotics in the treatment of severe acute pancreatitis (SAP). Methods We searched the PubMedbase Cochrane Library Medline, the Chinese Biomedical document Service Database (CBMN), the Chinese Journal of Science and Technology Database (VIPP), and the Chinese Journal Full-text Database (CNKI). Full text Database of Wanfang academic Journals, The clinical randomized controlled trial of probiotic therapy for SAP was investigated, and the results were analyzed by Review Manager5.3 software. The results were included in 12 RCT studies. Meta-analysis of 910 patients showed that there were no significant differences in the mortality rate (RR0.97), the incidence of multiple organ dysfunction (RRR0.72), the incidence of multiple organ dysfunction (RRR0.72), and the pancreatic infection rate (RR0.7695) and the pancreatic associated infection rate (RR0.7695) in the probiotics group and the control group (RRR0.97 / 95CI0.541 / 1.07 P0.12), and there was no significant difference in the incidence of multiple organ dysfunction (RRR0.72 / 95) and pancreatic infection rate (RR0.766 / 95CIT 0.541.07 / P0.12). However, there were significant differences between the two groups in the length of stay [MD-3.74-95CI-6.37 ~ 1.12] and the incidence of intestinal ischemic necrosis [RRR 11.39 ~ 95%]. Conclusion probiotics can not effectively improve the clinical parameters of SAP patients and increase the risk of intestinal ischemic necrosis. But it can shorten the patient's stay in hospital.
【作者单位】：西南医科大学附属医院药学部;西南医科大学药学院临床药学系;
【基金】：2016年度重庆市出版专项资金资助项目
【分类号】：R576

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