IL-8在HBV相关慢加急性肝衰竭中的临床意义

发布时间：2018-02-24 21:42

本文关键词： 白细胞介素- 乙型肝炎病毒慢加急性肝功能衰竭病毒载量　出处：《安徽医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨白细胞介素(IL)-8在乙型肝炎相关慢加急性肝功能衰竭(HBV-ACLF)中的临床价值。方法对62例HBV-ACLF患者和57例HBV患者采用免疫组化技术分析肝组织IL-8水平与分布情况,利用ELISA技术测定血清IL-8水平。对其HBV-DNA和血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、总胆红素和肌酐等肝功能指标水平亦进行同步测定。结果HBV-ACLF患者肝组织及血清中IL-8含量均明显高于HBV患者及健康对照者;且经Pearson相关性分析,HBV500 IU/ml时血清IL-8与HBV-DNA水平呈正相关性(r=0.416,P0.05)。与HBV患者和健康对照者相比,HBVACLF患者血清中ALT、AST、ALP、总胆红素和肌酐含量均有明显增加。血清IL-8与肝损害程度(ALT、AST水平)亦呈显著正相关性(r=0.247、0.317,P0.05)。结论 HBV-ACLF患者肝组织及外周血IL-8水平显著升高,且血清IL-8水平与患者肝脏炎症损伤和病情严重程度有关。
[Abstract]:Objective to investigate the clinical value of interleukin-8 (IL-8) in hepatitis B associated chronic and acute hepatic failure (HBV-ACLF). Methods 62 cases of HBV-ACLF and 57 cases of HBV were analyzed by immunohistochemical technique for the level and distribution of IL-8 in liver tissue. The level of serum IL-8 was measured by ELISA technique. The levels of HBV-DNA and alt, aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin and creatinine were also measured synchronously. The content of IL-8 in liver tissue and serum of HBV-ACLF patients was significantly higher than that of HBV patients and healthy controls. After Pearson correlation analysis, the serum IL-8 and HBV-DNA levels were positively correlated with that of HBV patients and healthy controls. Compared with HBV patients and healthy controls, the levels of alt, total bilirubin and creatinine in serum of patients with HBV A CLF were significantly increased, and the level of serum IL-8 was significantly higher than that of patients with HBV and healthy controls. Conclusion the levels of IL-8 in liver tissue and peripheral blood of HBV-ACLF patients were significantly increased. The level of serum IL-8 was related to the severity of liver inflammation.
【作者单位】：安徽医科大学第二附属医院检验科;
【基金】：国家自然科学基金(编号:81171662) 安徽省卫生计生委科研计划项目(全科医学临床科研课题)(编号:2016QK014) 安徽省高校省级自然科学重点项目(编号:KJ2016A351)
【分类号】：R575.3;R512.62

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