急性胰腺炎患者血清白介素-22及hs-CRP水平的变化及意义

发布时间：2018-02-26 05:09

本文关键词： 急性胰腺炎白细胞介素-22 超敏 C-反应蛋白　出处：《青海大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:通过测定不同分型的急性胰腺炎(acute pancreatitis,AP)患者的血清中白介素-22(interleukin-22,IL-22)以及超敏C反应蛋白(hypersensitive-CRP,hs-CRP)的水平,探讨人血清中IL-22、hs-CRP在AP疾病发生发展中的变化及其临床意义,为AP患者进行临床诊疗等方面提供新的思路。方法:采用双抗体夹心酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)测定13例重症急性胰腺炎(severe acute pancreatitis,SAP)、22例轻症急性胰腺炎(mild acute pancreatitis,MAP)患者及25例健康对照受试者血清IL-22、hs-CRP的水平,并将各组之间的数据进行分析比较。结果:(1)SAP组和MAP组患者血清IL-22水平明显高于对照组,且SAP组患者血清IL-22明显高于MAP组,差异有统计学意义(P0.05);(2)所有AP患者血清hs-CRP水平均高于健康对照组,且SAP组患者水平明显高于MAP组,差异有统计学意义(P0.05);(3)所有实验组(SAP组、MAP组)患者血清hs-CRP水平均与血清IL-22水平成正相关,差异有统计学意义(P0.05)。结论:1.血清IL-22可能参与了AP发病的发生过程,对于其疾病诊断可能有指导意义;2.血清hs-CRP可能与AP的发展存在一定的联系,可能对判断AP炎症程度有一定意义;3.血清IL-22可能参与hs-CRP的代谢调节过程。
[Abstract]:Objective: to investigate the changes and clinical significance of interleukin-22 interleukin-22 (IL-22) and hypersensitive-CRPhs-CRPP in serum of patients with acute pancreatitis (AP) by measuring the levels of IL-22hs-CRP in the serum of patients with acute pancreatitis (AP) of different types, and to explore the clinical significance of IL-22hs-CRP in the occurrence and development of AP. Methods: enzyme enzyme linked immunosorbent assay (Elisa) with double antibody sandwich enzyme linked immunosorbent Assay Elisa was used to determine 13 cases of severe acute pancreatitis (SAP) and 22 patients with mild acute pancreatitis (AAP) and 25 cases with mild acute pancreatitis (AP) by using enzyme enzyme linked immunosorbent assay (Elisa) with enzyme enzyme linked immunosorbent assay (Elisa) for clinical diagnosis and treatment of AP. Serum levels of IL-22 hs-CRP in healthy control subjects, Results the serum IL-22 level in SAP group and MAP group was significantly higher than that in control group, and the serum IL-22 level in SAP group was significantly higher than that in MAP group. The serum hs-CRP level of all AP patients was higher than that of healthy control group, and the level of SAP group was significantly higher than that of MAP group. The difference was statistically significant (P 0.05) the serum hs-CRP level was positively correlated with the serum IL-22 level in all the experimental group (map group). Conclusion: 1. Serum IL-22 may be involved in the pathogenesis of AP. Serum hs-CRP may be associated with the development of AP, and may have some significance in judging the degree of AP inflammation. 3. Serum IL-22 may participate in the metabolic regulation of hs-CRP.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R576

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