高胆红素血症肝硬化患者静息态功能MRI脑功能变化

发布时间：2018-02-26 06:35

本文关键词： 肝硬化磁共振成像脑功能局部一致性高胆红素血症　出处：《中国医学影像技术》2017年05期 　论文类型：期刊论文

【摘要】：目的采用静息态功能MRI局部一致性(ReHo)的方法,探讨血氨正常高间接胆红素肝硬化患者脑功能的改变。方法分别对53例血氨正常高间接胆红素肝硬化患者(肝硬化组)及60名健康志愿者(正常对照组)行静息态fMRI,采用ReHo方法分析,比较并获得2组ReHo值的差异性脑区。将2组差异性脑区的ReHo值与间接胆红素浓度进行相关分析。结果与正常对照组相比较,肝硬化组ReHo值增高的脑区包括左背外侧额上回、左眶部额上回、左顶下缘角回、左中央前回、右尾状核、右豆状壳核、右岛叶、右嗅皮质(P均0.001),ReHo值降低的脑区包括左枕上回、左枕中回、左楔叶、左岛盖部额下回、右中央旁小叶、右楔前叶、右枕中回、双侧舌回及双侧小脑(P均0.001)。肝硬化患者右岛叶和右豆状壳核的平均ReHo值与间接胆红素浓度呈正相关(r=0.32,P=0.021)。结论血氨正常高间接胆红素肝硬化患者静息态脑功能存在增强和减弱,间接胆红素浓度与部分脑区功能相关,高间接胆红素对成人脑功能也有一定的影响。
[Abstract]:Objective To study the changes of brain function in patients with liver cirrhosis with normal high and indirect bilirubin by using the method of resting state function MRI local consistency ( ReHo ) . The results were compared with those of normal control group . Results Compared with normal control group , the brain area with increased ReHo value in cirrhosis group included left occipital gyrus , left middle lobe , right wedge lobe , left central anterior gyrus , right central lobe , right wedge anterior leaflet , right occipital gyrus , bilateral lingual gyrus and bilateral cerebellum ( P < 0.001 ) . The average Rehove value of right island lobe and right bean shell nucleus was positively correlated with the concentration of indirect bilirubin ( r = 0.32 , P = 0.021 ) . Conclusion There is an increase and decrease in resting state brain function in patients with normal blood ammonia normal and indirect bilirubin . The concentration of indirect bilirubin is related to the function of some brain regions , and the high indirect bilirubin has some influence on adult brain function .

【作者单位】：安徽医科大学第一附属医院放射科;
【基金】：国家自然科学基金(81171326、81571308)
【分类号】：R445.2;R575.5

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