2015年晴隆县健康人群乙肝HBsAg、抗-HBs血清学监测分析

发布时间：2018-02-27 15:05

本文关键词： 乙肝血清学健康人群监测防控措施　出处：《现代预防医学》2017年02期 　论文类型：期刊论文

【摘要】：目的了解晴隆县健康人群病毒性乙型肝炎(简称乙肝)表面抗原、表面抗体水平及表面抗原抗体同时阳性率,探讨乙肝感染情况,为防控策略和措施提供科学依据。方法采用随机抽样方法,从全县14个乡镇中每个乡镇随机抽取一个行政村,每个行政村随机抽取8个年龄组共30人采静脉血分离血清,采用酶联免疫吸附法(ELISA)检测乙肝表面抗原(HBs Ag)、乙肝表面抗体(抗-HBs)。结果 2015年晴隆县健康人群HBs Ag、抗-HBs、HBs Ag和抗-HBs同时阳性率分别为4.52%、49.23%、1.73%;各年龄段之间、各乡镇之间差异均有统计学意义(P0.01);定点接种抗-HBs阳性率为52.73%,大于逐户上门接种的42.39%,差异有统计学意义(P0.01)。8~12月龄组和5~6岁组HBs Ag、HBs Ag和抗-HBs同时阳性率呈现2个高峰,8~12月龄组抗-HBs阳性率最高,以后随着年龄的增长逐渐降低,特别是5~6岁组后降幅明显;城乡结合部、边远少数民族乡镇呈现HBs Ag、HBs Ag和抗-HBs同时阳性率偏高,抗-HBs阳性率偏低的现象。结论提高乙肝疫苗免疫及时率及基础免疫全程接种率,加强边远少数民族乡镇、城乡结合部人群乙肝疫苗查漏补种和5岁以上人群每3~5年一次乙肝疫苗加强免疫以及加强乙肝防控措施宣传教育,是预防和控制乙肝疫情的关键。
[Abstract]:Objective to investigate the level of surface antigen, surface antibody and positive rate of surface antigen antibody in healthy people in Qinglong County, and to explore the situation of hepatitis B infection. Methods A random sampling method was used to select one administrative village from each of the 14 townships in the county. 30 people from 8 age groups were randomly selected from each of the 14 townships in the county. Elisa was used to detect HBs Agn and anti-HBs antibody (anti-HBsAg). Results in 2015, the positive rates of HBs Ag, anti-HBs Ag and anti-HBs in healthy people in Qinglong County were 4.52%, 49.23% and 1.73%, respectively, among the healthy people in Qinglong County, in 2015, the positive rates of HBeAg, anti-HBs and anti-HBs were 4.52%, 49.23% and 1.73%, respectively. The positive rate of anti-HBs in targeted inoculation was 52.73, higher than that in door-to-door inoculation (42.39). The difference was statistically significant in 12 months old group and 5 ~ 6 year old group. The positive rates of anti-HBs Ag and anti-HBs both showed two peaks at the same time. The positive rate of anti-HBs was the highest in the age group. Later, with the increase of age, especially in 5- 6 years old group, the decrease was obvious, and the positive rate of HBs Ag and anti-HBs was higher in the remote minority villages and towns in the urban and rural areas, and the positive rate of anti-HBs was higher than that in the urban and rural areas. Conclusion to improve the immunization rate of hepatitis B vaccine and the whole immunization rate of basic immunization, to strengthen the remote minority villages and towns, the positive rate of anti-HBs is on the low side, and the positive rate of anti-HBs is on the low side. It is the key to prevent and control hepatitis B epidemic situation in the population of urban and rural conjunctions, such as hepatitis B vaccine screening and replanting, strengthening immunization once every 3 ~ 5 years and strengthening the propaganda and education of hepatitis B prevention and control measures in the population over 5 years of age.
【作者单位】：贵州省晴隆县疾病预防控制中心;
【分类号】：R512.62

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