臭氧治疗非酒精性脂肪肝:细胞因子水平的变化

发布时间：2018-02-27 16:49

  本文关键词： 脂肪肝 臭氧 瘦素 外科手术中自体血液回收 组织构建 组织工程 非酒精性脂肪肝 一氧化氮 前列腺素F-a 白细胞介素 高敏C-反应蛋白 氧化低密度脂蛋白 国家自然科学基金　出处：《中国组织工程研究》2015年07期 　论文类型：期刊论文

【摘要】：背景:臭氧溶于血液治疗疾病目前已作为指南之外的补充治疗或者辅助治疗方法,但研究报告多为临床疗效描述性观察,臭氧治疗是否影响血清细胞因子尚不清楚。目的:观察臭氧自体血回输治疗对非酒精性脂肪肝患者血清一氧化氮、前列腺素F-2a、白细胞介素6、高敏C-反应蛋白、氧化低密度脂蛋白、瘦素的影响。方法:选取2013年10月至2014年6月于新疆医科大学第一附属医院肝病科住院治疗的非酒精性脂肪肝患者36例,按患者意愿分为臭氧治疗组和对照组,对照组单独护肝药物治疗,治疗组在护肝药物治疗基础上加用臭氧自体血回输治疗,所有伴有2型糖尿病和(或)血脂紊乱的入选者均接受专业的降糖和(或)降脂治疗,测定所有入选者治疗前后血清一氧化氮、前列腺素F-2a、白细胞介素6、高敏C-反应蛋白、氧化低密度脂蛋白、瘦素水平。结果与结论:与对照组相比,治疗组患者治疗前血清中前列腺素F-2a和瘦素水平较高(P≤0.05),治疗前后两组患者瘦素差值水平差异无显著性意义(P0.05),而前列腺素F-2a治疗前后差值水平差异仍具有显著性意义(P=0.02)。提示臭氧自体血回输治疗可降低非酒精性脂肪肝患者瘦素水平,改善非酒精性脂肪肝患者瘦素抵抗,对非酒精性脂肪性肝病患者远期预后可能有预防及治疗作用。
[Abstract]:Background: ozone dissolved in blood has been used as a supplementary or adjuvant therapy for diseases outside of the guidelines, but most of the research reports are descriptive observations of clinical efficacy. Objective: to observe the effects of ozone autotransfusion on serum nitric oxide, prostaglandin F-2a, interleukin-6, Gao Min C-reactive protein in patients with non-alcoholic fatty liver. Effects of oxidized low density lipoprotein (LDL) and leptin. Methods: from October 2013 to June 2014, 36 patients with non-alcoholic fatty liver were enrolled in the Department of Hepatology, the first affiliated Hospital of Xinjiang Medical University. According to the wishes of the patients, the patients were divided into the ozone treatment group and the control group, the control group was treated with liver protection drugs alone, and the treatment group was treated with ozone autologous blood transfusion on the basis of the liver protection drug therapy. All patients with type 2 diabetes mellitus and / or dyslipidemia received professional hypoglycemic and / or lipid lowering therapy. Serum nitric oxide, prostaglandin F-2a, interleukin-6, Gao Min C-reactive protein were measured before and after treatment. Levels of oxidized low density lipoprotein and leptin. Results and conclusions: compared with the control group, The serum levels of prostaglandin F-2a and leptin in the treatment group were higher than those in the control group (P 鈮，

本文编号：1543507