柔肝化纤颗粒联合粒细胞集落刺激因子治疗慢性乙型肝炎肝衰竭的疗效观察

发布时间：2018-03-01 21:36

本文关键词： 慢性乙型肝炎肝衰竭柔肝化纤颗粒粒细胞集落刺激因子/G-CSF 临床疗效　出处：《辽宁中医杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的:评价柔肝化纤颗粒联合粒细胞集落刺激因子(G-CSF)对慢性乙型肝炎肝衰竭患者的治疗效果。方法:将2011年2月—2013年6月间该院收治并确诊为慢性乙型肝炎肝衰竭的95例患者按随机数字表法将患者随机分为3组,其中A组给予常规内科综合支持治疗,B组在上述基础上加用G-CSF皮下注射治疗,C组在B组的基础上加用柔肝化纤颗粒。结果:与治疗前相比,3组TBIL、PT、ET均明显改善(P0.05),B、C组比A组改善更为明显,而C组比B组明显改善(P0.05);3组ALT也均明显下降(P0.05),但下降程度比较差异无统计学意义(P0.05);与治疗前相比,A组HBV DNA无明显变化(P0.05),但B、C组血清HBV DNA均明显下降(P0.05),而且C组比B组下降更为明显(P0.05);治疗8周后3组HBV DNA阴转率及治疗总有效率比较差异有统计学意义(P0.05),C组均最高。结论:在内科治疗基础上,联合柔肝化纤颗粒与G-CSF治疗能明显改善患者肝功能、凝血及内毒素指标,提高临床治疗效果。
[Abstract]:Objective: to evaluate the therapeutic effect of Rugan Huaxian granule combined with granulocyte colony stimulating factor G-CSF on patients with chronic hepatitis B liver failure. Methods: from February 2011 to June 2013, the patients with chronic hepatitis B liver failure were treated in our hospital and diagnosed as chronic hepatitis B liver failure. Ninety-five patients with exhaustion were randomly divided into three groups according to the method of random digital table. Group A was treated with routine comprehensive medical support therapy and group B was treated with G-CSF subcutaneous injection on the basis of G-CSF. Results: compared with before treatment, TBILP PTT in group A was significantly improved than that in group B (P 0.05) and that in group B was treated with subcutaneous injection of G-CSF. The improvement was more obvious than that in group A, The ALT of group C was significantly improved than that of group B (P 0.05), but there was no significant difference in the degree of HBV DNA between group A and group B (P 0.05), but the serum HBV DNA of group C was significantly lower than that of group C (P 0.05), and the ratio of group C to group C was lower than that of group C. After 8 weeks of treatment, the negative conversion rate of HBV DNA and the total effective rate of treatment in group B were significantly higher than those in group C. conclusion: on the basis of medical treatment, the negative conversion rate of HBV DNA and the total effective rate of treatment were the highest in group B. The combination of Rugan Huaxian granule and G-CSF can obviously improve the liver function, coagulation and endotoxin, and improve the clinical therapeutic effect.
【作者单位】：广西中医药大学;广西中医药大学第一附属医院;
【基金】：国家自然科学基金项目(81403382,81660745) 广西卫生厅项目(GZZC14-04)
【分类号】：R512.62;R575.3

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